Alterperylenol

Alterperylenol is an orange-red antifungal pigment from the plant pathogen Alternaria sp.. The fungal metabolite has an inhibitory effect on telomerase activity with an IC50 of 30 µM in the TRAP assay, making it an interesting object of research in the development of new anticancer drugs. In cancer cells, the enzyme telomerase prevents the continuous shortening of chromosome ends and is thus crucial for the infinite ability of degenerated cells to divide. Inhibition of telomerase results in premature cell death and could therefore represent a starting point for the treatment of tumor diseases. Potential mode of action/Key words: Targeting DNA, Telomerase inhibitor, Potential anticancer, Potential antitumor