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Artikelnummer:
7100056
CAS Nr.:
59-05-2
Formel:
C20H22N8O5
Synonyme:
Methotrexate (Mexate®, Folex®, Rheumatrex®, Amethopterin, MTX)
Molekulargewicht:
454,44 g/mol
Methotrexate interacts with DNA production. This stops cell growth and division, resulting in the slowing or stopping of cancer growth. Since cancer cells, in general, divide faster and with less error-correcting than healthy cells, cancer cells are more sensitive to this damage. Methotrexate competes with folic acid uptake in cells. This results in a folic acid deficiency in these cells and leads to cell death. By affecting the folic acid uptake, methotrexate also alters DNA replication and cell division. Cancer cells take up methotrexate faster than normal cells (because they are rapidly dividing and thus replicate their DNA more frequently), causing their cell death.
Pharmarohstoffe bilden die Grundlage zur Herstellung von Arzneimitteln. Sie können in 3 Kategorien unterteilt werden: Naturstoffe sind Arzneimittel mit pflanzlichen Inhaltsstoffen, sog. Phytopharmaka. Sie werden mittlerweile zum Großteil nicht mehr aus biologischem ...