The flavonoids fisetin and hesperetin have several pharmaceutical effects, like antioxidative and anti-inflammatory. Fisetin is also known for being neuroprotective and a promising agent for Alzheimer-treatment. A recent publication is concentrating on the anti-leukemia property of these two phytochemicals.
Adan A. et al. have investigated the antiproliferative and apoptotic actions on human HL60 acute promyelocytic leukemia cells.
Fisetin and hesperetin treatment are modulating cell proliferation, cell division, apoptosis and altering signaling pathways. They showed a disruption of mitochondrial membrane potential together with increased caspase-3 activity. This publication demonstrates that fisetin and hesperetin, as many other phytochemicals, have anticancer properties.
- Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice. Currais A, Prior M, Dargusch R, Armando A, Ehren J, Schubert D, Quehenberger O, Maher P. Aging Cell. 2014 Apr;13(2):379-90. doi: 10.1111/acel.12185. Epub 2013 Dec 17.
- The pleiotropic effects of fisetin and hesperetin on human acute promyelocytic leukemia cells are mediated through apoptosis, cell cycle arrest, and alterations in signaling networks. Adan A, Baran Y. Tumour Biol. 2015 Jun 17. [Epub ahead of print]