In mouse melanoma cells paeonol had an effect on cell proliferation, apoptosis and the secretion of proinflammatory cytokines, like TNF-α, IL-1β, IL-6 and TGF-β. In vivo the results showed an attenuation of lung metastases accompanied by a downregulation of proinflammatory cytokines in the serum. The authors indicate that the anti-tumor activity of this compound is mainly reached by interruption of NF-κB and STAT3 signaling pathways. Hence natural compounds like paeonol have a promising potential as adjuvant cancer therapy.

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References:

  • Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Colotta F1, Allavena P, Sica A, Garlanda C, Mantovani A. Carcinogenesis. 2009 Jul;30(7):1073-81. doi: 10.1093/carcin/bgp127. Epub 2009 May 25.
  • Paeonol inhibits B16F10 melanoma metastasis In vitro and In Vivo via disrupting proinflammatory cytokines-mediated NF-κB and STAT3 pathways. Zhang L1,2, Tao L1, Shi T2, Zhang F1, Sheng X1, Cao Y1, Zheng S1, Wang A1,3, Qian W4, Jiang L2, Lu Y1,3. IUBMB Life. 2015 Oct;67(10):778-88. doi: 10.1002/iub.1435. Epub 2015 Oct 10.