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Sequence: [Cys1-Cys11, Cys3-Cys15]; H-Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2
Apamin, which has been isolated from bee venom, is the smallest neurotoxic polypeptide known. It is the only polypeptide neurotoxin that passes the blood-brain barrier. It has several features in common with the snake and scorpion neurotoxins: like these, apamin is a low-molecular-weight basic peptide, and the molecule is crosslinked by disulfide bridges.