Huwentoxin-I

Article number:

5250046

Chemical description:

Sequence: [Cys2-Cys17, Cys9-Cys22,Cys16-Cys29]; H-Ala-Cys-Lys-Gly-Val-Phe-Asp-Ala-Cys-Thr-Pro-Gly-Lys-Asn-Glu-Cys-Cys-Pro-Asn-Arg-Val-Cys-Ser-Asp-Lys-His-Lys-Trp-Cys-Lys-Trp-Lys-Leu-OH

Molecular weight:

3750,45 g/mol

Lethal neurotoxin. Binds to the nicotinic acetylcholine receptor. Blocks neuromuscular transmission. Possess presynaptic activity that affects the release of neurotransmitters from autonomic nerve endings of both cholinergic and adrenergic neuroeffector junctions. Selectively inhibits N-type calcium channel and has only very weak effect on L-type calcium channel. Has virtually no effect on muscle sodium channels but are potent inhibitor of neuronal TTX-sensitive channels, especially Nav1.7

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Huwentoxin-I

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