Imperatoxin A

Article number:


Chemical description:

Sequence: [Cys3-Cys17, Cys10-Cys21, Cys16-Cys32]; H-Gly-Asp-Cys-Leu-Pro-His-Leu-Lys-Arg-Cys-Lys-Ala-Asp-Asn-Asp-Cys-Cys-Gly-Lys-Lys-Cys-Lys-Arg-Arg-Gly-Thr-Asn-Ala-Glu-Lys-Arg-Cys-Arg-OH

Molecular weight:

3758,40 g/mol

Imperatoxin A has been isolated from the venom of the emperor Scorpion Pandinus imperator. Imperatoxin A is a strong agonist of ryanodine receptors (calcium release channels). This toxin induces voltage- and concentration-dependent subconductance states in both skeletal (RYR1 and RYR3) and cardiac (RYR2) ryanodine receptors by binding to a single, cytosolically accessible site different from the ryanodine binding site. Imperatoxin A enhances calcium release.

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Imperatoxin A

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