omega-Conotoxin MVIIC

Article number:

5250011

Formula:

C106H178N40O32S7

Chemical description:

Sequence: [Cys1-Cys16, Cys8-Cys20, Cys15-Cys26 ]; H-Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-NH2

Molecular weight:

2749,30 g/mol

Omega-CgTx-MVIIC inhibits presynaptic Ca2+ channels, including the Ca2+ channels responsible for Ca2+ uptake by rat brain synaptosomes, the P-type Ca2+ channels in cerebellar Purkinje cells, and a significant fraction of Omega-CgTx-GVIA-resistant currents in hippocampal CA1 neurons. Omega-CgTx-MVIIC also presents an inhibition of Omega-CgTx-GVIA-resistant depolarization-induced neurotransmetter release in cerebellar neurons of rats.

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omega-Conotoxin MVIIC

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