omega-Conotoxin SO-3

Article number:


Chemical description:

Sequence: [Cys2-Cys17, Cys9-Cys21, Cys16-Cys26 ]; H-Arg-Cys-Lys-Ala-Ala-Gly-Lys-Pro-Cys-Ser-Arg-Ile-Ala-Tyr-Asn-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2

Molecular weight:

2717,23 g/mol

Omega-conotoxins act at presynaptic membranes, they bind and block voltage-sensitive calcium channels (VSCC). This peptide selectively targets N-type voltage-sensitive calcium channels. Has no effect on R-type calcium currents, voltage-sensitive sodium currents, delayed rectifier potassium currents and transient outward potassium currents. Displays an analgesic potency similar to MVIIA in a range of acute and chronic pain models in rodents, but has less adverse effects compared with identical dosages of MVIIA injected intrathecally.

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omega-Conotoxin SO-3

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