Psalmotoxin 1 PcTx1

Article number:

5250049

Formula:

C200H312N62O57S6

Chemical description:

Sequence: [Cys3-Cys18, Cys10-Cys23, Cys17-Cys33 ]; H-Glu-Asp-Cys-Ile-Pro-Lys-Trp-Lys-Gly-Cys-Val-Asn-Arg-His-Gly-Asp-Cys-Cys-Glu-Gly-Leu-Glu-Cys-Trp-Lys-Arg-Arg-Arg-Ser-Phe-Glu-Val-Cys-Val-Pro-Lys-Thr-Pro-Lys-Thr-OH

Molecular weight:

7693,70 g/mol

Potently and selectively blocks the H(+)-gated sodium channel ASIC1a (acid-sensitive ion channel 1a). The blockade is rapid and reversible. Psalmotoxin 1 loses its capacity to block ASIC1a as soon as this subunit is associated with another member of the family (ASIC2a or ASIC3). The toxin can distinguish between the two ASIC1 splice variants ASIC1a and ASIC1b.

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Psalmotoxin 1 PcTx1

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