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Sequence: [Cys1-Cys15, Cys3-Cys11]; H-Cys-Ser-Cys-Lys-Asp-Met-Ser-Asp-Lys-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp-OH
Sarafotoxin-A has been isolated from the venom of the Snaker Atractaspis engaddensis. This toxin presents a vasoconstrictor activity. This compound has a close structural homology to the endothelin family. Sarafotoxin-A causes cardiac arrest probably as a result of coronary vasospasm. LD50 is 0.015 mg/kg by intravenous injection for sarafotoxin-A.