Article number:




Chemical description:

Sequence: [Cys7-Cys21, Cys14-Cys26, Cys20-Cys33 ]; H-Gly-Val-Asp-Lys-Ala-Gly-Cys-Arg-Tyr-Met-Phe-Gly-Gly-Cys-Ser-Val-Asn-Asp-Asp-Cys-Cys-Pro-Arg-Leu-Gly-Cys-His-Ser-Leu-Phe-Ser-Tyr-Cys-Ala-Trp-Asp-Leu-Thr-Phe-Ser-Asp-OH

Molecular weight:

4495,08 g/mol

SNX-482 has been isolated from the venom of the Spider Hysterocrates gigas (African tarantula). This toxin modulates the R-type current associated with the class a1E calcium channel Cav2.3 (CACNA1E). SNX-482 antagonizes channel activation by inducing a depolarizing shift in the activation potential, thus preventing the channel from undergoing normal membrane depolarization. SNX-482 acts rapidly and in a poorly reversible manner.

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