Tertiapin-Q

Article number:

5250050

CAS No.:

252198-49-5

Formula:

C106H174N34O25S4

Chemical description:

Sequence: [Cys3-Cys14, Cys5-Cys18 ]; H-Ala-Leu-Cys-Asn-Cys-Asn-Arg-Ile-Ile-Ile-Pro-His-Gln-Cys-Trp-Lys-Lys-Cys-Gly-Lys-Lys-NH2

Molecular weight:

2460,00 g/mol

Neurotoxin with presynaptic activity, that blocks the inwardly rectifying Kir1.1 (KCNJ1) and Kir3.1/3.4 (KCNJ3/KCNJ5) potassium channels with high affinity by binding to the M1-M2 linker region of these channels in a 1:1 stoichiometry. Tertiapin-Q also inhibits calcium-activated large conductance BK-type (KCNMA/KCNMB) potassium channels in a concentration-, and voltage-dependent manner, in addition to inhibiting Kir3.1/3.2 (KCNJ3/KCNJ6) heteromultimer potassium channels. It can prevent dose-dependently acetylcholine(ACh)-induced atrioventricular block in mammalian hearts.

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Tertiapin-Q

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