{"id":48339,"date":"2019-02-13T16:38:04","date_gmt":"2019-02-13T15:38:04","guid":{"rendered":"https:\/\/www.cfmot.de\/adcs\/"},"modified":"2021-09-13T12:22:01","modified_gmt":"2021-09-13T10:22:01","slug":"adcs","status":"publish","type":"page","link":"https:\/\/www.cfmot.de\/en\/adcs\/","title":{"rendered":"ADCs"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"48339\" class=\"elementor elementor-48339 elementor-42215\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9a6177b elementor-section-full_width elementor-section-height-min-height elementor-section-height-default elementor-section-items-middle\" data-id=\"9a6177b\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-39010b7\" data-id=\"39010b7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f0079f9 elementor-widget elementor-widget-heading\" data-id=\"f0079f9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">ADCs<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2ae19d5f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2ae19d5f\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-157dd0e2\" data-id=\"157dd0e2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1002a1bf elementor-widget elementor-widget-heading\" data-id=\"1002a1bf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Innovationen for a<br>better world<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-57c4d3a elementor-widget elementor-widget-heading\" data-id=\"57c4d3a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">We supply the keys to new therapies<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2f44a1a8 elementor-widget elementor-widget-text-editor\" data-id=\"2f44a1a8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Antibody Drug Conjugates (ADCs) are a new approach in the development of innovative drugs for cancer therapy. This fundamental technology has already been described in 1908 by Paul Ehrlich and awarded with the Nobel Prize in Medicine. Human antibodies are coupled to highly potent toxins (conjugation) to selectively kill cancer cells and facilitate healing. This technology also reduces side effects.<\/p>\n<p>Leading biotech and pharmaceutical companies rely on Cfm Oskar Tropitzsch GmbH in the sustainable sourcing of toxins as payloads for ADCs \u2013 including substances with IC50 values in the picomolar range and novel or special mode of action.<\/p>\n<p>Another challenge is the worldwide logistic of highly-potent products, to meet all country-specific requirements. The active exchange with ADC experts worldwide enables us to offer additional services: we provide conjugation partners, contract manufacturing specialists and safety rating experts.<\/p>\n<div class=\"page\" title=\"Page 10\">\n<div class=\"section\">\n<div class=\"layoutArea\">\n<div class=\"column\">\n<p>Our service includes the active marketing of potential payload candidates, often discovered by innovative start-ups. The \u201eyoung savages\u201c see in the marketing of their substances the clear advantage of having access to the existing, dense global Cfm network.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b210a44 elementor-widget elementor-widget-text-editor\" data-id=\"b210a44\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The Cfm-Team would like to make your life easier and therefore we provide a SD-File which includes all payloads and reagents for Antibody Drug Conjugation (ADC).<\/p>\n<p>Cfm Oskar Tropitzsch GmbH supplies unique molecules as payloads for ADCs.<\/p>\n<p>These payloads are highly and ultra-toxic drugs, i.e. cytotoxic and\/or cytostatic molecules, effective at a low dosage and therefore classified as highly potent APIs (HPAPIs)<\/p>\n<p><a title=\"Form SDF\" href=\"https:\/\/www.cfmot.de\/en\/cytotoxin-sd-file-download\/\">Request the Structure Data File (SDF)<\/a><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-3ba5785a\" data-id=\"3ba5785a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b6cc858 elementor-widget elementor-widget-shortcode\" data-id=\"b6cc858\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\"><div class=\"linker-box\" style=\"border-color:#009eda\"><h3 style=\"background: #009eda\">Services<\/h3><ul><li style=\"color: #009eda\"><span class=\"inner-link\"><a href=\"https:\/\/www.cfmot.de\/en\/unsere-dienstleistungen\/adcs-en\/#contract-manufacturing-2\">Contract Manufacturing <span class=\"icon-angle-right\"><\/span><\/a><\/span><\/li><li style=\"color: #009eda\"><span class=\"inner-link\"><a href=\"https:\/\/www.cfmot.de\/en\/unsere-dienstleistungen\/adcs-en\/#payload-sourcing\">Payload Sourcing <span class=\"icon-angle-right\"><\/span><\/a><\/span><\/li><li style=\"color: #009eda\"><span class=\"inner-link\"><a href=\"https:\/\/www.cfmot.de\/en\/unsere-dienstleistungen\/adcs-en\/#payload-linker-conjugation\">Payload Linker Conjugation <span class=\"icon-angle-right\"><\/span><\/a><\/span><\/li><li style=\"color: #009eda\"><span class=\"inner-link\"><a href=\"https:\/\/www.cfmot.de\/en\/unsere-dienstleistungen\/adcs-en\/#logistics-services-for-hpapis\">Logistics Services for HPAPIs <span class=\"icon-angle-right\"><\/span><\/a><\/span><\/li><li style=\"color: #009eda\"><span class=\"inner-link\"><a href=\"https:\/\/www.cfmot.de\/en\/unsere-dienstleistungen\/adcs-en\/#marketing-of-payload-candidates\">Marketing of Payload Candidates <span class=\"icon-angle-right\"><\/span><\/a><\/span><\/li><li style=\"color: #009eda\"><span class=\"inner-link\"><a href=\"https:\/\/www.cfmot.de\/en\/unsere-dienstleistungen\/adcs-en\/#network-service-for-adcs\">Network Service for ADCs <span class=\"icon-angle-right\"><\/span><\/a><\/span><\/li><\/ul><\/div><div class=\"linker-box\" style=\"border-color:#009eda\"><h3 style=\"background: #009eda\">Categories<\/h3><ul><li style=\"color: #009eda\"><span class=\"inner-link\"><a href=\"https:\/\/www.cfmot.de\/en\/produktgruppe\/adcs-en\/\">All products <span class=\"icon-angle-right\"><\/span><\/a><\/span><\/li><li style=\"color: #009eda\"><span class=\"inner-link\"><a href=\"https:\/\/www.cfmot.de\/en\/produktgruppe\/reagents-for-adcs\/\">Reagents for ADCs <span class=\"icon-angle-right\"><\/span><\/a><\/span><\/li><li style=\"color: #009eda\"><span class=\"inner-link\"><a href=\"https:\/\/www.cfmot.de\/en\/produktgruppe\/toxins-with-linkers\/\">Toxins with Linkers <span class=\"icon-angle-right\"><\/span><\/a><\/span><\/li><\/ul><\/div><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-11aca84 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"11aca84\" data-element_type=\"section\" data-e-type=\"section\" id=\"success\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-623e403\" data-id=\"623e403\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7d7eb01 elementor-widget elementor-widget-heading\" data-id=\"7d7eb01\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">The Poison of the green death cap mushroom<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6699701 elementor-widget elementor-widget-heading\" data-id=\"6699701\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Alpha-Amanitin for ADC Applications<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-017ac84 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"017ac84\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-284e045\" data-id=\"284e045\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0b59fdc elementor-widget elementor-widget-text-editor\" data-id=\"0b59fdc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>We are active in the product segment of Antibody Drug Conjugates since 2014 and are mainly working on the payload side. First substances were quickly established in the market. As a competent partner, Cfm Oskar Tropitzsch GmbH was soon asked for alpha-amanitin, the highly potent poison of the green death cap mushroom, which is acting in the picomolar range.<\/p>\n<p>Toxins generally require special treatment; but such poisons were something special even for us. Our team led by Michael Sch\u00e4ffler bundled the know-how, found trustworthy sources and solutions for secure logistics right up to the first customers on the US West Coast.<\/p>\n<p>After research and due diligence, we found a highly qualified manufacturer in Europe who had been working with alpha-amanitin for several years and perfected the extraction from the green death cap mushroom. The challenges were that green dash cap mushrooms can not be cultivated and about one gram of alpha-amanitin requires about 20 kilograms of fresh, wild collected mushrooms. We had inquiries for more than 10 grams, and the tendency was increasing.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-212e740 elementor-widget elementor-widget-text-editor\" data-id=\"212e740\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"page\" title=\"Page 11\">\n<div class=\"layoutArea\">\n<div class=\"column\">\n<p>To find a solution, our team became creative: we wondered if the production of alpha-amanitin would be possible by fermentation. Such a process could equalize the supply bottleneck, lower the price and thus accelerate research at universities and research institutions.<\/p>\n<p>Michael Sch\u00e4ffler used his contacts, explained challenges, set transparency in the market overview and convinced a long-time Cfm partner company of the project.<\/p>\n<p>A detailed consideration of risk and potential resulted in an \u201eGo\u201c for the screening to find the right strain. Not even six months after the launch of this project, we were able to safely supply alpha-amanitin by fermentation. Our partner established a reproducible process for production and purification. With a significantly reduced price, we took responsiblity for our clients in order to speed up research to cure patients.<\/p>\n<\/div>\n<\/div>\n<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-9e09f40\" data-id=\"9e09f40\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ccfd5d2 elementor-widget elementor-widget-image\" data-id=\"ccfd5d2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.cfmot.de\/wp-content\/uploads\/elementor\/thumbs\/adcs_production-o4f7mkf2hmf04hfnnrw41gcpj884xm80iegum3fnk0.jpg\" title=\"adcs_production\" alt=\"ADCs Production\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3f66f38 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3f66f38\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-5a19e11\" data-id=\"5a19e11\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7b5a69f elementor-widget elementor-widget-image\" data-id=\"7b5a69f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"622\" src=\"https:\/\/www.cfmot.de\/wp-content\/uploads\/2019\/02\/adcs_project_of_the_year.jpg\" class=\"attachment-large size-large wp-image-43036\" alt=\"ADCs Project of the year\" srcset=\"https:\/\/www.cfmot.de\/wp-content\/uploads\/2019\/02\/adcs_project_of_the_year.jpg 800w, https:\/\/www.cfmot.de\/wp-content\/uploads\/2019\/02\/adcs_project_of_the_year-300x233.jpg 300w, https:\/\/www.cfmot.de\/wp-content\/uploads\/2019\/02\/adcs_project_of_the_year-768x597.jpg 768w, https:\/\/www.cfmot.de\/wp-content\/uploads\/2019\/02\/adcs_project_of_the_year-450x350.jpg 450w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b506394 subtitle elementor-widget elementor-widget-text-editor\" data-id=\"b506394\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #009eda;\">Michael Sch\u00e4ffler<\/span><br \/>Senior Project Manager<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-a253148\" data-id=\"a253148\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7707a5f quote elementor-widget elementor-widget-text-editor\" data-id=\"7707a5f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Project of the year 2016<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-112b42e white elementor-widget elementor-widget-text-editor\" data-id=\"112b42e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Winner of the Bavarian Export Prize in the field of Services<br \/><\/strong><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Innovationen for a better world We supply the keys to new therapies Antibody Drug Conjugates (ADCs) are a new approach in the development of innovative drugs for cancer therapy. This fundamental technology has already been described in 1908 by Paul Ehrlich and awarded with the Nobel Prize in Medicine. Human antibodies are coupled to highly [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":42628,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-48339","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ADCs - Cfm Oskar Tropitzsch GmbH<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cfmot.de\/en\/adcs\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ADCs - Cfm Oskar Tropitzsch GmbH\" \/>\n<meta property=\"og:description\" content=\"Innovationen for a better world We supply the keys to new therapies Antibody Drug Conjugates (ADCs) are a new approach in the development of innovative drugs for cancer therapy. This fundamental technology has already been described in 1908 by Paul Ehrlich and awarded with the Nobel Prize in Medicine. 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