{"id":48391,"date":"2019-02-14T11:14:03","date_gmt":"2019-02-14T10:14:03","guid":{"rendered":"https:\/\/www.cfmot.de\/fermentation-products\/"},"modified":"2020-11-23T16:23:17","modified_gmt":"2020-11-23T15:23:17","slug":"fermentation-products","status":"publish","type":"page","link":"https:\/\/www.cfmot.de\/en\/fermentation-products\/","title":{"rendered":"Fermentation Products"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"48391\" class=\"elementor elementor-48391 elementor-42217\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6573a38c elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"6573a38c\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-26af3553\" data-id=\"26af3553\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-71ce8ca8 elementor-widget elementor-widget-heading\" data-id=\"71ce8ca8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Fermentation Products<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5b1ce5cf elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5b1ce5cf\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-1d3cf9f6\" data-id=\"1d3cf9f6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3176370e elementor-widget elementor-widget-heading\" data-id=\"3176370e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Small molecules,<br>huge impact<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-79011912 elementor-widget elementor-widget-heading\" data-id=\"79011912\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">800 Fermentation Products are within our portfolio<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5bf05d58 elementor-widget elementor-widget-text-editor\" data-id=\"5bf05d58\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Fermentation products are mainly produced by microbes and have a low molar mass of about 800 g \/mol. Due to their tiny size, small molecules, according to the Rule of Five (oral bioavailability according to Christopher Lipinski), are able to penetrate cells and to act there. The currently approved drugs (antibiotics, etc.) are mainly low molecular weight compounds. Cfm Oskar Tropitzsch GmbH offers more than 800 fermentation products. The applications are almost unlimited. Whether pharmaceutical, agro-biotech or food analysis: fermentation products always play an important role. On behalf of our customers, we conduct screenings with our partners to find new substances for new applications. If these substances are isolated, a complicated up-scaling process follows &#8211; in order to increase the production quantities from milligrams to grams or even kilograms.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-2b7ff7d9\" data-id=\"2b7ff7d9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6e9e6c55 elementor-widget elementor-widget-shortcode\" data-id=\"6e9e6c55\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\"><div class=\"linker-box\" style=\"border-color:#0069b4\"><h3 style=\"background: #0069b4\">Services<\/h3><ul><li style=\"color: #0069b4\"><span class=\"inner-link\"><a href=\"https:\/\/www.cfmot.de\/en\/unsere-dienstleistungen\/fermentation-products\/#contract-manufacturing\">Contract Manufacturing <span class=\"icon-angle-right\"><\/span><\/a><\/span><\/li><li style=\"color: #0069b4\"><span class=\"inner-link\"><a href=\"https:\/\/www.cfmot.de\/en\/unsere-dienstleistungen\/fermentation-products\/#product-sourcing\">Product Sourcing <span class=\"icon-angle-right\"><\/span><\/a><\/span><\/li><li style=\"color: #0069b4\"><span class=\"inner-link\"><a href=\"https:\/\/www.cfmot.de\/en\/unsere-dienstleistungen\/fermentation-products\/#screening-for-new-products\">Screening for New Products <span class=\"icon-angle-right\"><\/span><\/a><\/span><\/li><li style=\"color: #0069b4\"><span class=\"inner-link\"><a href=\"https:\/\/www.cfmot.de\/en\/unsere-dienstleistungen\/fermentation-products\/#isotope-labeled-mycotoxin-reference-standards\">Isotope-Labeled Mycotoxin Reference Standards <span class=\"icon-angle-right\"><\/span><\/a><\/span><\/li><li style=\"color: #0069b4\"><span class=\"inner-link\"><a href=\"https:\/\/www.cfmot.de\/en\/unsere-dienstleistungen\/fermentation-products\/#regulatory-support\">Regulatory Support <span class=\"icon-angle-right\"><\/span><\/a><\/span><\/li><\/ul><\/div><div class=\"linker-box\" style=\"border-color:#0069b4\"><h3 style=\"background: #0069b4\">Categories<\/h3><ul><li style=\"color: #0069b4\"><span class=\"inner-link\"><a href=\"https:\/\/www.cfmot.de\/en\/produktgruppe\/fermentation-products\/\">All products <span class=\"icon-angle-right\"><\/span><\/a><\/span><\/li><li style=\"color: #0069b4\"><span class=\"inner-link\"><a href=\"https:\/\/www.cfmot.de\/en\/produktgruppe\/antibiotics\/\">Antibiotics <span class=\"icon-angle-right\"><\/span><\/a><\/span><\/li><li style=\"color: #0069b4\"><span class=\"inner-link\"><a href=\"https:\/\/www.cfmot.de\/en\/produktgruppe\/apoptosis\/\">Apoptosis <span class=\"icon-angle-right\"><\/span><\/a><\/span><\/li><li style=\"color: #0069b4\"><span class=\"inner-link\"><a href=\"https:\/\/www.cfmot.de\/en\/produktgruppe\/isotope-labeled-mycotoxins\/\">Isotope Labeled Mycotoxins <span class=\"icon-angle-right\"><\/span><\/a><\/span><\/li><li style=\"color: #0069b4\"><span class=\"inner-link\"><a href=\"https:\/\/www.cfmot.de\/en\/produktgruppe\/mycotoxins\/\">Mycotoxins <span class=\"icon-angle-right\"><\/span><\/a><\/span><\/li><li style=\"color: #0069b4\"><span class=\"inner-link\"><a href=\"https:\/\/www.cfmot.de\/en\/produktgruppe\/mycotoxin-standard-solutions\/\">Mycotoxin Standard Solutions <span class=\"icon-angle-right\"><\/span><\/a><\/span><\/li><li style=\"color: #0069b4\"><span class=\"inner-link\"><a href=\"https:\/\/www.cfmot.de\/en\/produktgruppe\/protein-kinase-inhibitors\/\">Protein Kinase Inhibitors <span class=\"icon-angle-right\"><\/span><\/a><\/span><\/li><\/ul><\/div><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-046864b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"046864b\" data-element_type=\"section\" data-e-type=\"section\" id=\"success\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3058003\" data-id=\"3058003\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0b4b167 elementor-widget elementor-widget-heading\" data-id=\"0b4b167\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">New ways in cancer therapy<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f4e09df elementor-widget elementor-widget-heading\" data-id=\"f4e09df\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">We overcome hurdles<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-bb11f41 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bb11f41\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-f3a0acf\" data-id=\"f3a0acf\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1bc00b6 elementor-widget elementor-widget-text-editor\" data-id=\"1bc00b6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Non-small cell lung cancer is a huge problem in our industrial society. Pharmaceutical companies around the world are trying to develop a targeted cancer therapy. One of our US customers found a promising approach via the Hsp90 inhibitor. Hsp90, short for heat shock protein, stabilizes a number of proteins responsible for the survival of cancer cells. The hypothesis: If Hsp90 is inhibited, cancer cells can no longer be repaired and the cancer can be combated.<\/p>\n<p>Geldanamycin is a biologically active chemical compound, a benzoquinone of ansamycin, produced by the bacterium Streptomyces hygroscopicus. Geldanamycin was the agent of choice for our customer to fight the treacherous lung cancer.<\/p>\n<p>The substance is available on the market in milligram quantities. Our customer urgently required 5 kilograms for his research in a strictly defined quality. Our research showed that there was no suitable manufacturer available and the substance would only be obtainable with enormous lead time and the greatest financial outlay for process development.<\/p>\n<p>The task for the fermentation team around Michael Scha\u0308ffler, Lisa Meier and Alexander Glombik as QM commissioner was: 5 kilograms of Geldanamycin, sustainably produced in a non-GMP environment (but transferable), available at short notice and reasonably priced.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-462f741\" data-id=\"462f741\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-aa7b703 elementor-widget elementor-widget-text-editor\" data-id=\"aa7b703\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The key to success was the contact to the natural product unit of a pharmaceutical company. Michael Scha\u0308ffler asked his business partner if the substance Geldanamycin was known. The question was answered in affirmative, confirming a long-standing experience with the molecule and the will to accept the project and to examine the availability of production capacities. Furthermore, an internal approval was necessary, whether an actual sale of the goods to Cfm was possible.<\/p>\n<p>Big corporations and quick decisions &#8211; often this is mutually exclusive. In this case, we were pleasantly surprised: Our team realized a meeting and convinced the responsible management: Cfm received a special status from the manufacturer.<\/p>\n<p>Thanks to the availability of appropriate sized fermenters, free production slots and our know-how, we quickly had the opportunity to obtain the required 5 kilograms and bring our customer\u2018s project a decisive step ahead.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-92b03b4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"92b03b4\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-4194da6\" data-id=\"4194da6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4167445 elementor-widget elementor-widget-image\" data-id=\"4167445\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"497\" src=\"https:\/\/www.cfmot.de\/wp-content\/uploads\/2019\/02\/fermentation_products_michael_schaffler-1.jpg\" class=\"attachment-large size-large wp-image-43082\" alt=\"Fermentation Products Michael Sch\u00e4ffler\" srcset=\"https:\/\/www.cfmot.de\/wp-content\/uploads\/2019\/02\/fermentation_products_michael_schaffler-1.jpg 800w, https:\/\/www.cfmot.de\/wp-content\/uploads\/2019\/02\/fermentation_products_michael_schaffler-1-300x186.jpg 300w, https:\/\/www.cfmot.de\/wp-content\/uploads\/2019\/02\/fermentation_products_michael_schaffler-1-768x477.jpg 768w, https:\/\/www.cfmot.de\/wp-content\/uploads\/2019\/02\/fermentation_products_michael_schaffler-1-450x280.jpg 450w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4f97a24 subtitle elementor-hidden-tablet elementor-hidden-phone elementor-widget elementor-widget-text-editor\" data-id=\"4f97a24\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #0069b4;\">Michael Sch\u00e4ffler<\/span><br \/>\nSenior Project Manager<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-a5ef16e\" data-id=\"a5ef16e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7f5c11a elementor-widget elementor-widget-image\" data-id=\"7f5c11a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"497\" src=\"https:\/\/www.cfmot.de\/wp-content\/uploads\/2019\/02\/cfm_fermention_products-1.jpg\" class=\"attachment-large size-large wp-image-43074\" alt=\"Cfm Fermentation Products\" srcset=\"https:\/\/www.cfmot.de\/wp-content\/uploads\/2019\/02\/cfm_fermention_products-1.jpg 800w, https:\/\/www.cfmot.de\/wp-content\/uploads\/2019\/02\/cfm_fermention_products-1-300x186.jpg 300w, https:\/\/www.cfmot.de\/wp-content\/uploads\/2019\/02\/cfm_fermention_products-1-768x477.jpg 768w, https:\/\/www.cfmot.de\/wp-content\/uploads\/2019\/02\/cfm_fermention_products-1-450x280.jpg 450w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Small molecules,huge impact 800 Fermentation Products are within our portfolio Fermentation products are mainly produced by microbes and have a low molar mass of about 800 g \/mol. Due to their tiny size, small molecules, according to the Rule of Five (oral bioavailability according to Christopher Lipinski), are able to penetrate cells and to act [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":43068,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-48391","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Fermentation Products - Cfm Oskar Tropitzsch GmbH<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cfmot.de\/en\/fermentation-products\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fermentation Products - Cfm Oskar Tropitzsch GmbH\" \/>\n<meta property=\"og:description\" content=\"Small molecules,huge impact 800 Fermentation Products are within our portfolio Fermentation products are mainly produced by microbes and have a low molar mass of about 800 g \/mol. 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