{"id":48997,"date":"2019-02-19T10:52:31","date_gmt":"2019-02-19T09:52:31","guid":{"rendered":"https:\/\/www.cfmot.de\/englerin-a\/"},"modified":"2019-02-19T10:52:32","modified_gmt":"2019-02-19T09:52:32","slug":"englerin-a","status":"publish","type":"post","link":"https:\/\/www.cfmot.de\/en\/englerin-a\/","title":{"rendered":"Englerin A"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"48997\" class=\"elementor elementor-48997 elementor-48991 elementor-bc-flex-widget\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-51b13fc elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"51b13fc\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4c043f9\" data-id=\"4c043f9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f11cabd elementor-widget elementor-widget-text-editor\" data-id=\"f11cabd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Screening of plant extracts in search of new agents to treat cancer resulted in the discovery of Englerin A. A natural product, isolated from Phyllanthus engleri, shows potent selective cytotoxicity against renal cancer cells. But very little was known about its mechanism of action.<\/p>\n<p>Recently it was recovered that sesquiterpene (-)-englerin\u2005A was selectively killing renal cancer cells through activation of calcium-permeable nonselective transient receptor potential canonical (TRPC) calcium channels. TRPC4\/5 activation raises the calcium concentration in the renal cancer cells which leads to cell death.<\/p>\n<p>Again a natural compound is showing novel opportunities for drug discovery. Please check out our website. Cfm Oskar Tropitzsch GmbH offers a broad range of phytochemicals for your research projects.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-db8e4be btn elementor-widget elementor-widget-button\" data-id=\"db8e4be\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-size-sm\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Go to product<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f92f85b elementor-widget elementor-widget-text-editor\" data-id=\"f92f85b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4>References:<\/h4>\n<ul class=\"refrenzen\">\n<li><em>(-)-Englerin\u2005A is a potent and selective activator of TRPC4 and TRPC5 calcium channels. Akbulut Y, Gaunt HJ, Muraki K, Ludlow MJ, Amer MS, Bruns A, Vasudev NS, Radtke L, Willot M, Hahn S, Seitz T, Ziegler S, Christmann M, Beech DJ, Waldmann H. Angew Chem Int Ed Engl. 2015 Mar 16;54(12):3787-91. doi: 10.1002\/anie.201411511. Epub 2015 Feb 23.<\/em><\/li>\n<li><em>Renal cancer-selective Englerin A induces multiple mechanisms of cell death and autophagy. Williams RT, Yu AL, Diccianni MB, Theodorakis EA, Batova A. J Exp Clin Cancer Res. 2013 Aug 20;32:57. doi: 10.1186\/1756-9966-32-57.<\/em><\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Screening of plant extracts in search of new agents to treat cancer resulted in the discovery of Englerin A. A natural product, isolated from Phyllanthus engleri, shows potent selective cytotoxicity against renal cancer cells. But very little was known about its mechanism of action. Recently it was recovered that sesquiterpene (-)-englerin\u2005A was selectively killing renal [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":48995,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[48],"tags":[],"class_list":["post-48997","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog-en-2"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Englerin A - Cfm Oskar Tropitzsch GmbH<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cfmot.de\/en\/englerin-a\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Englerin A - Cfm Oskar Tropitzsch GmbH\" \/>\n<meta property=\"og:description\" content=\"Screening of plant extracts in search of new agents to treat cancer resulted in the discovery of Englerin A. 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