{"id":49108,"date":"2019-02-19T11:57:00","date_gmt":"2019-02-19T10:57:00","guid":{"rendered":"https:\/\/www.cfmot.de\/paeonol-an-actor-against-cancer-related-inflammation-cri\/"},"modified":"2019-02-19T11:57:02","modified_gmt":"2019-02-19T10:57:02","slug":"paeonol-an-actor-against-cancer-related-inflammation-cri","status":"publish","type":"post","link":"https:\/\/www.cfmot.de\/en\/paeonol-an-actor-against-cancer-related-inflammation-cri\/","title":{"rendered":"Paeonol &#8211; an actor against cancer related inflammation (CRI)"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"49108\" class=\"elementor elementor-49108 elementor-49102 elementor-bc-flex-widget\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-28736e0 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"28736e0\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-acc78c2\" data-id=\"acc78c2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-721499e elementor-widget elementor-widget-text-editor\" data-id=\"721499e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In mouse melanoma cells paeonol had an effect on cell proliferation, apoptosis and the secretion of proinflammatory cytokines, like TNF-\u03b1, IL-1\u03b2, IL-6 and TGF-\u03b2. In vivo the results showed an attenuation of lung metastases accompanied by a downregulation of proinflammatory cytokines in the serum. The authors indicate that the anti-tumor activity of this compound is mainly reached by interruption of NF-\u03baB and STAT3 signaling pathways. Hence natural compounds like paeonol have a promising potential as adjuvant cancer therapy.<\/p>\n<p>Please check out our website, Cfm Oskar Tropitzsch GmbH offers a broad range of natural products.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e017c96 elementor-align-center btn elementor-widget elementor-widget-button\" data-id=\"e017c96\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-size-sm\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Go to product<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-12823ea elementor-widget elementor-widget-text-editor\" data-id=\"12823ea\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>References:<\/p>\n<ul>\n<li>Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Colotta F1, Allavena P, Sica A, Garlanda C, Mantovani A. Carcinogenesis. 2009 Jul;30(7):1073-81. doi: 10.1093\/carcin\/bgp127. Epub 2009 May 25.<\/li>\n<li>Paeonol inhibits B16F10 melanoma metastasis In vitro and In Vivo via disrupting proinflammatory cytokines-mediated NF-\u03baB and STAT3 pathways. Zhang L1,2, Tao L1, Shi T2, Zhang F1, Sheng X1, Cao Y1, Zheng S1, Wang A1,3, Qian W4, Jiang L2, Lu Y1,3. IUBMB Life. 2015 Oct;67(10):778-88. doi: 10.1002\/iub.1435. Epub 2015 Oct 10.<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>In mouse melanoma cells paeonol had an effect on cell proliferation, apoptosis and the secretion of proinflammatory cytokines, like TNF-\u03b1, IL-1\u03b2, IL-6 and TGF-\u03b2. In vivo the results showed an attenuation of lung metastases accompanied by a downregulation of proinflammatory cytokines in the serum. The authors indicate that the anti-tumor activity of this compound is [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":49106,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[48],"tags":[],"class_list":["post-49108","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog-en-2"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Paeonol - an actor against cancer related inflammation (CRI) - Cfm Oskar Tropitzsch GmbH<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cfmot.de\/en\/paeonol-an-actor-against-cancer-related-inflammation-cri\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Paeonol - an actor against cancer related inflammation (CRI) - Cfm Oskar Tropitzsch GmbH\" \/>\n<meta property=\"og:description\" content=\"In mouse melanoma cells paeonol had an effect on cell proliferation, apoptosis and the secretion of proinflammatory cytokines, like TNF-\u03b1, IL-1\u03b2, IL-6 and TGF-\u03b2. In vivo the results showed an attenuation of lung metastases accompanied by a downregulation of proinflammatory cytokines in the serum. The authors indicate that the anti-tumor activity of this compound is [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.cfmot.de\/en\/paeonol-an-actor-against-cancer-related-inflammation-cri\/\" \/>\n<meta property=\"og:site_name\" content=\"Cfm Oskar Tropitzsch GmbH\" \/>\n<meta property=\"article:published_time\" content=\"2019-02-19T10:57:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2019-02-19T10:57:02+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.cfmot.de\/wp-content\/uploads\/2019\/02\/7500803_62-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"340\" \/>\n\t<meta property=\"og:image:height\" content=\"229\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"4cfabian\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"4cfabian\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.cfmot.de\\\/en\\\/paeonol-an-actor-against-cancer-related-inflammation-cri\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.cfmot.de\\\/en\\\/paeonol-an-actor-against-cancer-related-inflammation-cri\\\/\"},\"author\":{\"name\":\"4cfabian\",\"@id\":\"https:\\\/\\\/www.cfmot.de\\\/en\\\/#\\\/schema\\\/person\\\/cfda3575aaaf36e88c60c988a3a319e8\"},\"headline\":\"Paeonol &#8211; 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