{"id":74416,"date":"2020-04-09T10:34:49","date_gmt":"2020-04-09T08:34:49","guid":{"rendered":"https:\/\/www.cfmot.de\/sirolimus-an-accompanying-treatment-for-covid-19-in-elderly-persons\/"},"modified":"2020-04-09T10:36:16","modified_gmt":"2020-04-09T08:36:16","slug":"sirolimus-an-accompanying-treatment-for-covid-19-in-elderly-persons","status":"publish","type":"post","link":"https:\/\/www.cfmot.de\/en\/sirolimus-an-accompanying-treatment-for-covid-19-in-elderly-persons\/","title":{"rendered":"Sirolimus &#8211; An accompanying treatment for COVID-19 in elderly persons?!"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"74416\" class=\"elementor elementor-74416\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-835bac7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"835bac7\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ca9daa0\" data-id=\"ca9daa0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e664095 elementor-widget elementor-widget-text-editor\" data-id=\"e664095\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Researchers globally combat the COVID-19 pandemia. Data generated suggest that COVID-19 is a major threat for elderly in regards to being more dangerous and more severe. Even when a successful vaccine for SARS-CoV-2 becomes available, an additional drug might be necessary in order to boost the immune response in vaccinated but weakened persons.<\/p>\n<p>Rapamycin\/Sirolimus is commonly used as an immunosuppressant. Rapamycin and other compounds of this class target the so called mTOR pathway (<em>mechanistic Target of Rapamycin<\/em>). Paradoxically, this compound also exerts immunostimulatory effects such as boosting T cell response in reaction to pathogen infection and vaccination. (Ferrer IR, Araki K, Ford ML. Paradoxical aspects of rapamycin immunobiology in transplantation. Am J Transplant. 2011; 11:654\u201359. <a href=\"https:\/\/doi.org\/10.1111\/j.1600-6143.2011.03473.x%20PMID:21446969\">https:\/\/doi.org\/10.1111\/j.1600-6143.2011.03473.x PMID:21446969<\/a>).<\/p>\n<p>This would be not the first time a physiological paradox is discovered in clinical medicine. We refer here to the administration of beta-blockers to heart failure patients. In order to proof the effectiveness of Rapamycin to specific age-associated diseases, substantial pre-clinical validations applications in human trials will be necessary.<\/p>\n<p>&nbsp;<\/p>\n<p>Cfm Oskar Tropitzsch GmbH is working with Rapamycin for &gt;20 years. We can provide R&amp;D grade material as well as cGMP grade Rapamycin produced in Europe along with all required documents like CoA, SDS and an EDMF.<\/p>\n<p>&nbsp;<\/p>\n<p>Cfm provides \u2013 as usual &#8211; cutting-edge compounds to make the world a more-healthy place.<\/p>\n<p>Reach out to us for more information. michael.schaeffler@cfmot.de<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Researchers globally combat the COVID-19 pandemia. Data generated suggest that COVID-19 is a major threat for elderly in regards to being more dangerous and more severe. Even when a successful vaccine for SARS-CoV-2 becomes available, an additional drug might be necessary in order to boost the immune response in vaccinated but weakened persons. Rapamycin\/Sirolimus is [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":74410,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1,48,123,139,129],"tags":[],"class_list":["post-74416","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","category-blog-en-2","category-news","category-pharmaceutical-products","category-pharmaprodukte"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Sirolimus - An accompanying treatment for COVID-19 in elderly persons?! - Cfm Oskar Tropitzsch GmbH<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cfmot.de\/en\/sirolimus-an-accompanying-treatment-for-covid-19-in-elderly-persons\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sirolimus - An accompanying treatment for COVID-19 in elderly persons?! - Cfm Oskar Tropitzsch GmbH\" \/>\n<meta property=\"og:description\" content=\"Researchers globally combat the COVID-19 pandemia. Data generated suggest that COVID-19 is a major threat for elderly in regards to being more dangerous and more severe. Even when a successful vaccine for SARS-CoV-2 becomes available, an additional drug might be necessary in order to boost the immune response in vaccinated but weakened persons. Rapamycin\/Sirolimus is [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.cfmot.de\/en\/sirolimus-an-accompanying-treatment-for-covid-19-in-elderly-persons\/\" \/>\n<meta property=\"og:site_name\" content=\"Cfm Oskar Tropitzsch GmbH\" \/>\n<meta property=\"article:published_time\" content=\"2020-04-09T08:34:49+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-04-09T08:36:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.cfmot.de\/wp-content\/uploads\/2020\/04\/woman-1031000_elderly_person_free-photos_pixabay-1024x770.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"770\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Michael.Schaeffler\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Michael.Schaeffler\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.cfmot.de\\\/en\\\/sirolimus-an-accompanying-treatment-for-covid-19-in-elderly-persons\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.cfmot.de\\\/en\\\/sirolimus-an-accompanying-treatment-for-covid-19-in-elderly-persons\\\/\"},\"author\":{\"name\":\"Michael.Schaeffler\",\"@id\":\"https:\\\/\\\/www.cfmot.de\\\/en\\\/#\\\/schema\\\/person\\\/27be9490c258e644757e598549f606cc\"},\"headline\":\"Sirolimus &#8211; An accompanying treatment for COVID-19 in elderly persons?!\",\"datePublished\":\"2020-04-09T08:34:49+00:00\",\"dateModified\":\"2020-04-09T08:36:16+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.cfmot.de\\\/en\\\/sirolimus-an-accompanying-treatment-for-covid-19-in-elderly-persons\\\/\"},\"wordCount\":246,\"image\":{\"@id\":\"https:\\\/\\\/www.cfmot.de\\\/en\\\/sirolimus-an-accompanying-treatment-for-covid-19-in-elderly-persons\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.cfmot.de\\\/wp-content\\\/uploads\\\/2020\\\/04\\\/woman-1031000_elderly_person_free-photos_pixabay.jpg\",\"articleSection\":[\"Blog\",\"Blog\",\"News\",\"Pharmaceutical Products\",\"Pharmaprodukte\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.cfmot.de\\\/en\\\/sirolimus-an-accompanying-treatment-for-covid-19-in-elderly-persons\\\/\",\"url\":\"https:\\\/\\\/www.cfmot.de\\\/en\\\/sirolimus-an-accompanying-treatment-for-covid-19-in-elderly-persons\\\/\",\"name\":\"Sirolimus - An accompanying treatment for COVID-19 in elderly persons?! 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