{"id":83871,"date":"2023-05-22T09:58:57","date_gmt":"2023-05-22T07:58:57","guid":{"rendered":"https:\/\/www.cfmot.de\/?p=83871"},"modified":"2023-05-22T09:58:57","modified_gmt":"2023-05-22T07:58:57","slug":"sugars-from-food-industry-to-drug-manufacturing","status":"publish","type":"post","link":"https:\/\/www.cfmot.de\/en\/sugars-from-food-industry-to-drug-manufacturing\/","title":{"rendered":"Sugars: from food industry to drug manufacturing"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"83871\" class=\"elementor elementor-83871 elementor-83853\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bdbec88 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bdbec88\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-27eacbb\" data-id=\"27eacbb\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d2631b9 elementor-widget elementor-widget-text-editor\" data-id=\"d2631b9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>When it comes to sugar, people first think of its function as an energy supplier and sweetener in food or, in a negative context, of the common disease <em>diabetes mellitus<\/em>. But sugar is more than an energy supplier and nobody can live without it.<\/p><p>Most probably only a minority is thinking of a group of chemically similar molecules with diverse (bio)chemical functions.<\/p><h4>Modification via glycosylation: dysfunction causes diseases<\/h4><p>The glycosylation of certain proteins, meaning the addition of sugar moieties to proteins, is essential e.g. for correct protein folding and activity, whereas dysfunction of glycosylation is related to various diseases. Aberrant protein glycosylation for example is a hallmark of cancer and specific glycans actively drive tumor development and progression.<\/p><p>Thus, correct glycosylation is a critical attribute that can also be used to optimize known active ingredients. During development and administration, potentially active drugs routinely display intolerances or suboptimum therapeutic efficacies due to poor physicochemical and pharmacological properties <em>in vivo.<\/em><\/p><h4>Glycoengineering: slow release of active substances<\/h4><p>Glycoengineering is reported as approach to improve active molecules, e.g. drugs or proteins, in terms of solubility, molecular stability, pharmacodynamic responses, and pharmacokinetic profiles (retardation effect). Besides, it is reported as strategy in cosmetics and perfume industry ensuring the slow release of the active substances over a certain period triggered by microbial or human glucosidases.<\/p><p>In addition, the glycosylation of known drugs may allow re-patenting of the new dosage form. One example in this regard is the modification of the well-known drug Paracetamol by the company 4GENE.<\/p><h4>Key effects of glycosylation:<\/h4><ul><li>Redesign of existing drugs<\/li><li>Circumvention of existing patents<\/li><li>Activity regulation<\/li><li>Retardation effect and controlled drug release<\/li><li>Solubility improvement<\/li><\/ul><p>\u00a0<\/p><p>For carbohydrate chemistry and related chemical modifications, the commercial availability of the required (protected) sugar intermediates in sufficient quality is of crucial importance.<\/p><p>At <strong>Cfm Oskar Tropitzsch<\/strong> we have the capabilities to provide protected carbohydrates, e.g. <strong>Monoacetone D-Glucose (MAG) and Diacetone-D-Glucose (DAG)<\/strong> from 1 kg up to bulk quantities. The product is manufactured by our experienced joint venture partner. Consistent quality and delivery reliability are guaranteed.<\/p><h4>Exemplary fields of applications:<\/h4><ul><li>Chemical synthesis<\/li><li>Pharmaceutical industry<\/li><li>Metal chelators<\/li><li>Glycosylation reactions<\/li><li>Cosmetic industry<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7b7796c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7b7796c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4fa4bdf\" data-id=\"4fa4bdf\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e17d297 elementor-widget elementor-widget-image\" data-id=\"e17d297\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"149\" src=\"https:\/\/www.cfmot.de\/wp-content\/uploads\/2023\/05\/Icons-1024x191.jpg\" class=\"attachment-large size-large wp-image-83844\" alt=\"\" srcset=\"https:\/\/www.cfmot.de\/wp-content\/uploads\/2023\/05\/Icons-1024x191.jpg 1024w, https:\/\/www.cfmot.de\/wp-content\/uploads\/2023\/05\/Icons-300x56.jpg 300w, https:\/\/www.cfmot.de\/wp-content\/uploads\/2023\/05\/Icons-768x144.jpg 768w, https:\/\/www.cfmot.de\/wp-content\/uploads\/2023\/05\/Icons-1536x287.jpg 1536w, https:\/\/www.cfmot.de\/wp-content\/uploads\/2023\/05\/Icons-2048x383.jpg 2048w, https:\/\/www.cfmot.de\/wp-content\/uploads\/2023\/05\/Icons-407x76.jpg 407w, https:\/\/www.cfmot.de\/wp-content\/uploads\/2023\/05\/Icons-800x150.jpg 800w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c163724 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c163724\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d390ac2\" data-id=\"d390ac2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7c93568 elementor-widget elementor-widget-text-editor\" data-id=\"7c93568\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>References<\/strong>:<\/p><p>PCT\/US2009\/035702<\/p><p>Synthesis, Biological Activity, and Molecular Modeling Studies of 1H-1,2,3-Triazole Derivatives of Carbohydrates as \uf061-Glucosidases Inhibitors; S. B. Ferreira, A. C. R. Sodero, M. F. C. Cardoso, E. S. Lima, C. R. Kaiser, F. P. Silva Jr., V. F. Ferreira; J. Med. Chem. 2010, 53: 2364-2375. <a href=\"https:\/\/doi.org\/10.1021\/jm901265h\">https:\/\/doi.org\/10.1021\/jm901265h<\/a><\/p><p>Synthesis of polysulfated heparin degradation product; J. Kuszmann, G. Medgyes, S.Boros; Pharmazie 2004; 59: 344-348. <br \/>Development of a Flexible and Robust Synthesis of Tetrahydrofuro[3,4-b]furan Nucleoside Analogues; D. A. Candito, Y. Ye, R. V. Qziroz, M. H. Reutershan, D. Witter, S. B Gadamsetty, H. Li, J. Saur\u00ed, S. E. Schneider, Y.-h. Lam, R. L. Palte; J. Org. Chem. 2021; 86: 5142-5151. <a href=\"https:\/\/doi.org\/10.1021\/acs.joc.0c02969\">https:\/\/doi.org\/10.1021\/acs.joc.0c02969<\/a><\/p><p>WO 2010\/036698 A1<\/p><p>US 2002\/0173632 A1<\/p><p>Targeting Glycosylation: A New Road for Cancer Drug Discovery; A. F. Costa, D. Campos, C. A. Reis, C. Gomes; Trends in Cancer 2020; 6(9): 757-766. <a href=\"https:\/\/doi.org\/10.1016\/j.trecan.2020.04.002\">https:\/\/doi.org\/10.1016\/j.trecan.2020.04.002<\/a><\/p><p>A new alternative tool to analyse glycosylation in pharmaceutical proteins based on infrared spectroscopy combined with nonlinear support vector regression; S. Hamla, P.-Y. Sacr\u00e9, A. Derenne, K.-M. Derfoufi, B. Cowper, C. I. Butr\u00e9, A. Delobel, E. Goormaghtigh, P. Hubert, E. Ziemons; Analyst 2022; 147: 1086-1098. <a href=\"https:\/\/doi.org\/10.1039\/D1AN00697E\">https:\/\/doi.org\/10.1039\/D1AN00697E<\/a><\/p><p>Glycosylation and Lipidation Strategies: Approaches for Improving Antimicrobial Peptide Efficacy; R. Bellavita, S. Braccia, S. Galdiero, A. Falanga; Pharmaceuticals 2023; 16(3): 439. <a href=\"https:\/\/doi.org\/10.3390\/ph16030439\">https:\/\/doi.org\/10.3390\/ph16030439<\/a><\/p><p>Glycosylation of Therapeutic Proteins: An Effective Strategy to Optimize Efficacy; R. J. Sol\u00e1, K. Griebenow; BioDrugs 2010; 24(1): 9-21. <a href=\"https:\/\/doi.org\/10.2165\/11530550-000000000-00000\">https:\/\/doi.org\/10.2165\/11530550-000000000-00000<\/a><\/p><p>4GENE <a href=\"https:\/\/4gene.de\/\">https:\/\/4gene.de\/<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>When it comes to sugar, people first think of its function as an energy supplier and sweetener in food or, in a negative context, of the common disease diabetes mellitus. But sugar is more than an energy supplier and nobody can live without it. Most probably only a minority is thinking of a group of [&hellip;]<\/p>\n","protected":false},"author":10,"featured_media":84368,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[48,133,139],"tags":[],"class_list":["post-83871","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog-en-2","category-news-en","category-pharmaceutical-products"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Sugars: from food industry to drug manufacturing - Cfm Oskar Tropitzsch GmbH<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cfmot.de\/en\/sugars-from-food-industry-to-drug-manufacturing\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sugars: from food industry to drug manufacturing - Cfm Oskar Tropitzsch GmbH\" \/>\n<meta property=\"og:description\" content=\"When it comes to sugar, people first think of its function as an energy supplier and sweetener in food or, in a negative context, of the common disease diabetes mellitus. 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