{"id":86344,"date":"2024-06-25T11:27:37","date_gmt":"2024-06-25T09:27:37","guid":{"rendered":"https:\/\/www.cfmot.de\/resiniferatoxin-the-worlds-hottest-chemical\/"},"modified":"2024-06-27T09:19:02","modified_gmt":"2024-06-27T07:19:02","slug":"resiniferatoxin-the-worlds-hottest-chemical","status":"publish","type":"post","link":"https:\/\/www.cfmot.de\/en\/resiniferatoxin-the-worlds-hottest-chemical\/","title":{"rendered":"Resiniferatoxin \u2013 the world&#8217;s hottest chemical in painkiller research"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"86344\" class=\"elementor elementor-86344 elementor-86337\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7dc9dc9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7dc9dc9\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-033f2b5\" data-id=\"033f2b5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-91b1440 elementor-widget elementor-widget-text-editor\" data-id=\"91b1440\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Resiniferatoxin is a natural substance found in Euphorbia resinifera. This plant grows in Morocco on the slopes of the Atlas Mountains. The milky sap of this plant contains a high concentration of resiniferatoxin.<br \/>Resiniferatoxin has a taste that is 500 to 1000 times hotter than capsaicin, which is found in peppers or chili.<br \/>On the Scoville scale, resiniferatoxin is considered the harshest chemical in the world, with a value of 16 billion. Even in very low concentrations, contact with the substance immediately causes severe burning pain.\u00a0<\/p><h4>Neurogenic inflammation and hypothermia<\/h4><p>Ingestion causes neurogenic inflammation and hypothermia in mammals. In experiments with rats, a temperature loss of 2-3 K was found within one hour. Resiniferatoxin leads to desensitization to neurogenic inflammation and causes chemical and thermal analgesia. The toxicity of resiniferatoxin is due to the specific stimulation of sensory receptors in the ganglia, particularly heat receptors.<br \/>The sensory neurons responsible for the perception of pain are stimulated cell-selectively via the activation of the transient receptor protein TRPV1 (Transient Receptor Potential Vanilloid 1).<\/p><p>TRPV1 is primaril found in sensory neurons that respond to damaging or potentially damaging stimuli, known as nociceptors. It cooperates with another receptor called TRPA1 to mediate the detection of noxius environmental stimuli. Activation of the TRPV1 leads to the sensation of burning heat and pain.<\/p><h4>Therapeutic target for pain management<\/h4><p>TRPV1 is an ion channel located in the plasma membrane of sensory neurons. Upon activation by various stimuli (such as heat, capsaicin or acid) TRPV1 becomes permeable to Calcium ions. This influx of calcium ions results in neuronal depolarization and subsequent pain signal transmission to the brain. Researchers have validated TRPV1 as a therapeutic target for pain management.<br \/>Resiniferatoxin is used in research to study pain mechanisms and to develop painkillers. The therapeutic window of RTX is broad, allowing complete desensitization of pain perception and neurogenic inflammation without causing unacceptable side effects. Therefore, it is a promising candidate for pain therapy.<\/p><p>Resiniferatoxin acts as an agonist at the TRPV1 receptor, it activates TRPV1 and, with prolonged use, causes a decrease in TRPV1 activity (desensitization), resulting in pain relief via the subsequent reduction in TRPV1-mediated release of inflammatory molecules after exposure to noxious stimuli. It leads to desensitization of the receptor.<\/p><p><strong>\u2192 We will be happy to advise you in more detail about this product. <a href=\"https:\/\/www.cfmot.de\/en\/produkt\/resiniferatoxin-2\/\">Just send us your inquiry<\/a>.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Resiniferatoxin is a natural substance found in Euphorbia resinifera. This plant grows in Morocco on the slopes of the Atlas Mountains. The milky sap of this plant contains a high concentration of resiniferatoxin.Resiniferatoxin has a taste that is 500 to 1000 times hotter than capsaicin, which is found in peppers or chili.On the Scoville scale, [&hellip;]<\/p>\n","protected":false},"author":10,"featured_media":86340,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[48,139,138],"tags":[],"class_list":["post-86344","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog-en-2","category-pharmaceutical-products","category-phytochemicals"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Resiniferatoxin \u2013 the world&#039;s hottest chemical in painkiller research - Cfm Oskar Tropitzsch GmbH<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cfmot.de\/en\/resiniferatoxin-the-worlds-hottest-chemical\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Resiniferatoxin \u2013 the world&#039;s hottest chemical in painkiller research - Cfm Oskar Tropitzsch GmbH\" \/>\n<meta property=\"og:description\" content=\"Resiniferatoxin is a natural substance found in Euphorbia resinifera. This plant grows in Morocco on the slopes of the Atlas Mountains. The milky sap of this plant contains a high concentration of resiniferatoxin.Resiniferatoxin has a taste that is 500 to 1000 times hotter than capsaicin, which is found in peppers or chili.On the Scoville scale, [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.cfmot.de\/en\/resiniferatoxin-the-worlds-hottest-chemical\/\" \/>\n<meta property=\"og:site_name\" content=\"Cfm Oskar Tropitzsch GmbH\" \/>\n<meta property=\"article:published_time\" content=\"2024-06-25T09:27:37+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-06-27T07:19:02+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.cfmot.de\/wp-content\/uploads\/2024\/06\/Resiniferatoxin-1600.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1600\" \/>\n\t<meta property=\"og:image:height\" content=\"1000\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Karin Bayer\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Karin Bayer\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.cfmot.de\\\/en\\\/resiniferatoxin-the-worlds-hottest-chemical\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.cfmot.de\\\/en\\\/resiniferatoxin-the-worlds-hottest-chemical\\\/\"},\"author\":{\"name\":\"Karin Bayer\",\"@id\":\"https:\\\/\\\/www.cfmot.de\\\/en\\\/#\\\/schema\\\/person\\\/0192b39a358835d45c94562d47c033c7\"},\"headline\":\"Resiniferatoxin \u2013 the world&#8217;s hottest chemical in painkiller research\",\"datePublished\":\"2024-06-25T09:27:37+00:00\",\"dateModified\":\"2024-06-27T07:19:02+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.cfmot.de\\\/en\\\/resiniferatoxin-the-worlds-hottest-chemical\\\/\"},\"wordCount\":396,\"image\":{\"@id\":\"https:\\\/\\\/www.cfmot.de\\\/en\\\/resiniferatoxin-the-worlds-hottest-chemical\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.cfmot.de\\\/wp-content\\\/uploads\\\/2024\\\/06\\\/Resiniferatoxin-1600.jpg\",\"articleSection\":[\"Blog\",\"Pharmaceutical Products\",\"Phytochemicals\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.cfmot.de\\\/en\\\/resiniferatoxin-the-worlds-hottest-chemical\\\/\",\"url\":\"https:\\\/\\\/www.cfmot.de\\\/en\\\/resiniferatoxin-the-worlds-hottest-chemical\\\/\",\"name\":\"Resiniferatoxin \u2013 the world's hottest chemical in painkiller research - 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