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Artikelnummer:
5250010
Chemische Beschreibung:
Sequence: [Cys1-Cys16, Cys8-Cys20, Cys15-Cys25 ]; H-Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2
Molekulargewicht:
2639,20 g/mol
Omega-conotoxin MVIIA has been isolated from the venom of the cone Conus magus. Omega-conotoxins act at presynaptic membranes, they bind and block voltage-sensitive calcium channels(VSCC). This toxin blocks N-type calcium channels (Cav2.2/CACNA1B). Omega-conotoxin MVIIA is available under the names Prialt by Neurex. It blocks acute pain in patients who no longerobtain relief from opiate drugs. I t is 100 to 1000 times more potent than morphine. This toxin blocks calcium channels it disable nerves that transmit pain signals.