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Article number:
5600018
CAS No.:
554-62-1
Formula:
C18H39NO3
Chemical description:
(2S,3S,4R)-2-aminooctadecane-1,3,4-triol
Synonyms:
4-D-Hydroxysphinganine
Molecular weight:
317,51 g/mol
Phytosphingosine is a sphingolipid endogenous to many organisms involved in cell signaling. Phytosphingosine displays anbibacterial activity (CL Fischer et al. Antimicrob. Agents Chemother. 2012 56:1157). Phytosphingosine can be taken up by E. coli and S. aureus and induce ultrastrucural damage (CL Fischer et al. Skin Pharmacol. Physiol. 2013 26:36). IC 50 value: Jurkat (Acute leukemic T-cells): IC50 = 3.75 µM (human). pKa: 11.91 (Predicted), pKb: 7.98 (Predicted). Phytosphingosine is a phospholipid and has anti-cancer activities. Phytosphingosine induces cell Apoptosis via caspase 8 activation and Bax translocation in cancer cells. Potential mode of action/Key words: Apoptosis inducer, Antibacterial, Anticancer, Induces Apoptosis
Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...