Bisbenzimid H 33342: Versatile Fluorescent Dye for Modern Research
Our product of the month is Bisbenzimide H 33342, also known by the synonyms Hoechst 33342 or HOE 33342. This fluorescent DNA dye has established itself for decades as an indispensable laboratory chemical in biomedical research. Its ability to specifically bind to adenine-thymine-rich regions of DNA makes it an important tool for cell biology, molecular […]
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Digitoxin: Renaissance of a Cardiac Glycoside
Digitoxin, a cardiac glycoside derived from the purple foxglove (Digitalis purpurea), is experiencing a remarkable renaissance in modern heart failure therapy thanks to the DIGIT-HF study. The study demonstrates that Digitoxin can significantly reduce the risk of death and hospital admission in patients with systolic heart failure (HFrEF) when added to standard therapy. Digitoxin as […]
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Making the Invisible Visible: D-Luciferin Free Acid as a Key to Sensitive Cellular Analysis
Bioluminescent imaging has become an indispensable tool in biomedical research over the past decades. At the heart of this technology lies a single molecule: D-Luciferin, particularly in its Free Acid form. D-Luciferin Free Acid (CAS No. 2591-17-5) is a synthetic derivative of the natural substrate found in fireflies (Photinus pyralis). It is produced entirely through […]
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Product of the Month September: Methanesulfonic Acid (MSA)
Methanesulfonic acid (MSA), also known as methylsulfonic acid or mesyl acid, is the simplest representative of the sulfonic acids. It is a colorless, odorless, viscous liquid characterized by high acidity and remarkable chemical stability. MSA is hygroscopic and possesses a wide electrochemical window.In laboratory-scale production, MSA can be synthesized by oxidizing methanethiol or dimethyldisulfide using […]
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Product of the Month August: Everolimus
Everolimus is a synthetic derivative of the natural compound Sirolimus (Rapamycin), originally isolated from the bacterium Streptomyces hygroscopicus found on Easter Island (Rapa Nui). As a member of the macrolide class and mTOR inhibitors, Everolimus boasts a remarkable range of applications. From transplant medicine to cancer research and laboratory technology. Everolimus was developed to optimize […]
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Rapamycin / Sirolimus: Laboratory Chemical of the Month for July
Rapamycin, also known as Sirolimus, was first discovered in the 1970s on Easter Island (Rapa Nui). Initially isolated as an antifungal agent, its diverse biological properties have led to a wide range of applications: 1. Laboratory Chemical: Rapamycin is extensively used in research, particularly for studying cell growth processes and signaling pathways. It is a […]
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Product of the Month May: Plant-based Cholesterol – Research Reagent
Cholesterol: An essential component of the lipid cocktail in vaccines For the administration of vaccines, a so-called “lipid cocktail” is required, in which cholesterol plays a central role. Lipids are largely water-insoluble natural substances that, together with the mRNA fragment, form lipid nano-particles. These particles protect the vaccine and enable its safe transport into the […]
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Active Ingredient of the Month December: Riboflavin-5′-Phosphate
Riboflavin-5′-phosphate is also known as flavin mononucleotide (FMN) and is an active form of vitamin B2 (riboflavin). It plays a central role in human metabolism and is used as a pharmaceutical active ingredient. Riboflavin is an essential vitamin found in milk, eggs, meat and green vegetables, for example. In the body, riboflavin is converted into […]
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Active ingredient of the month November: histamine dihydrochloride
The active ingredient of the month for November is histamine dihydrochloride. The main area of application for this is the treatment of acute myeloid leukemia (AML) in combination with interleukin-2 (IL-2). Histamine dihydrochloride is mainly used in maintenance therapy for adult patients with AML who are in initial remission. It is administered in specific treatment […]
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Active ingredient of the month October: zinc sulphate
Zinc sulfate is an inorganic compound. It occurs naturally in food and water. The human body relies on a certain amount of zinc, which is why it is used as a dietary supplement. Zinc sulfate is easily soluble in water. When heated to high temperatures, especially in the presence of reducing agents, it decomposes to […]
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Active ingredient of the month August: Everolimus
Our versatile active ingredient of the month for August, everolimus, is used in various medical fields. Originally developed as an immunosuppressant, everolimus has become increasingly important in oncology. Mode of action: suppresses cell proliferation and immune response of the body Everolimus belongs to the class of mTOR inhibitors (mammalian target of rapamycin). It binds to […]
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Active ingredient of the month for July: paclitaxel
Our active ingredient of the month, paclitaxel, is used to treat various types of cancer. Paclitaxel is able to inhibit the division and proliferation of cancer cells. Cytostatic agent from the Pacific oak Paclitaxel is a cytostatic agent and belongs to the group of taxanes. It is extracted from the bark of the Pacific yew […]
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