In search of endogenous proteins

Johannes Broichhagenwww.broichhagenlab.com In his lectures, summarized in his book “What is Life?”, the physicist Erwin Schrödinger described in the 1940s that “the course of life processes in an organism […] [shows] an admirable regularity and order that in inanimate matter does not find its equal”.[1] Almost 80 years later, we are still searching for the […]

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Plant of the Month June: Foxglove

The common foxglove, which belongs to the plantain family, is native to Central and Western Europe. Since it is also popular as a houseplant, it is also cultivated. As a biennial plant, it can grow to a remarkable height of up to two meters. The oval leaves of Digitalis purpurea are lance-shaped, the flowers are […]

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Daptomycin – a powerful weapon against multi-resistant germs

The antibiotic daptomycin is often considered the last weapon – it is supposed to help when other active ingredients fail due to resistant germs. Daptomycin was discovered and developed 30 years ago – but the mode of action was not 100 percent clear. In the meantime, scientists from the Universities of Bonn and Amsterdam have […]

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Avarol from sea sponges

Did you know that sea sponges produce drugs? Every day they protect themselves against their natural enemies with a multitude of active ingredients. Some of these substances, like Avarol, are already used successfully against viral diseases or cancer. Researchers are now trying to breed the sea sponges in order to obtain larger quantities of the […]

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IPTG (Isopropyl-β-d-thiogalactopyranosid) – Use in Molecular Biology

The synthetic carbohydrate isopropyl-β-D-thiogalactopyranoside (IPTG) is the isopropylthioglycoside of D-galactose. This reagent is particularly widespread in recombinant protein expression. This substance is often used in molecular biology. IPTG – important for the lactose metabolism of Escherichia coli This lac operon plays an important role in the lactose metabolism of various enteric bacteria, such as Escherichia […]

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Verrucarin A in cancer therapy

Pancreatic cancer (ductal pancreatic adenocarcinoma / PDA) is one of the most difficult cancers to treat. Common chemotherapeutic agents often only bring about a short-term improvement in symptoms and, unfortunately, experience has shown that they have little effect on the patient’s recovery. New types of therapy are urgently needed here.  This is where Verrucarin A […]

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DL-Dithiothreitol – DTT as key element in diagnostics

In today’s time when there is still no vaccine or medication against the corona virus, COVID 19 tests or antibody tests are particularly important in order to uncover and thus interrupt the chain of infection. One product is of particular importance in these test kits: DL-Dithiothreitol, in short: DTT Long-term partnership Cfm Oskar Tropitzsch GmbH […]

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Sirolimus - An accompanying treatment for COVID-19 in elderly persons?!

Sirolimus – An accompanying treatment for COVID-19 in elderly persons?!

Researchers globally combat the COVID-19 pandemia. Data generated suggest that COVID-19 is a major threat for elderly in regards to being more dangerous and more severe. Even when a successful vaccine for SARS-CoV-2 becomes available, an additional drug might be necessary in order to boost the immune response in vaccinated but weakened persons. Rapamycin/Sirolimus is […]

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Sirolimus - An accompanying treatment for COVID-19 in elderly persons?!

Rapamycin – Eine Zusatztherapie bei der COVID-19 Behandlung von Senioren?!

Forscher weltweit bekämpfen die COVID-19-Pandämie. Die generierten Daten legen nahe, dass COVID-19 eine große Bedrohung gerade für ältere Menschen darstellt, da die Krankheitsverläufe gefährlicher und schwerer sind. Selbst wenn ein erfolgreicher Impfstoff gegen SARS-CoV-2 verfügbar wird, kann ein zusätzliches Medikament erforderlich sein, um die Immunantwort bei geimpften, aber geschwächten Personen zu stärken. Rapamycin / Sirolimus […]

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Sirolimus

Sirolimus API

Sirolimus / Rapamycin for facial angiofibromas A Sirolimus vaseline® 0.1% jelly produced by pharmacies according to an prescription shows success in the treatment of facial angiofibromas. Facial angiofirbomas are a symptom of tuberous sclerosis (TSC also Pringle-Bourneville disease). Tuberous sclerosis is a multi-system disease. At least for the treatment of facial angiofibromas, a rapamycin vaseline® […]

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Combat COVID-19 with the natural compound OSW-1!?

Oxysterol-binding Protein (OSBP), required for the cellular replication of many types of viruses can be inhibited by the natrual compound (OSW-1). The OSW-1 induced reduction of OSBP inhibit Enterovirus replication prophylactically in cells. These are the findings published in Antiviral Research 117 (2015) 110-114 and Antiviral Research 170 (2019) 104548. We assume, that COVID-19 (CORONAVIRUS) […]

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Alpine Winter Conference

Visit us at the 2nd Alpine Winter Conference in St. Anton, taking place Jan. 19.- Jan 23, 2020 The Conference topics will include: Accelerating Drug Discovery by Intelligence Augmentation Drug Discovery Tales Frontiers of Synthetic Chemistry Innovation and Inspiration from Natural Products Predictive ADME Sciences: Striking a Balance Between in Silico and Experimental Work? Protein […]

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