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Article number:
5600025
CAS No.:
108852-90-0
Formula:
C32H37NO13
Chemical description:
(7S,9S)-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-7-[(2R,4S,5S,6S)-5-hydroxy-4-[(2S)-2-methoxymorpholin-4-yl]-6-methyloxan-2-yl]oxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
Molecular weight:
643,64 g/mol
Nemorubicin is a morpholinyl analog of doxorubicin. It is more cytotoxic and less cardiotoxic against multidrug-resistant tumor cells. IC50= 0.08 µM. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for G-quadruplex DNA segments, stabilizing their structure. Potential mode of action/Key words: Targeting DNA, Acts via metabolite PNU 159682, Antitumoral, Cytotoxic
Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...