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Article number:
5600007
CAS No.:
163768-50-1
Formula:
C40H67N5O6
Chemical description:
(2S)-2-[[(2R,3R)-3-[(2S)-1-[(3R,4S,5S)-4-[[(2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-3-methylbutanoyl]-methylamino]-3-methoxy-5-methylheptanoyl]pyrrolidin-2-yl]-3-methoxy-2-methylpropanoyl]amino]-3-phenylpropanoic acid
Molecular weight:
745,99 g/mol
Auristatin F is a synthetic analog of Dolastatin 10. Auristatin F is a highly potent antimitotic agent.Auristatin F inhibits tubulin polymerization(1). Auristatin F-antibody cunjugates have proven to be successful anticancer agents.(2) 1. GR Pettit et al. Anticancer Drug Des. 1995 10:529. 2. SO Doronina et al. Nature Biotechnol. 2003 21:778. Auristatin F is a Tubulin inhibitor. Potential mode of action/Key words: Targeting Tubulin, Antimitotic, Anticancer
Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...