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Article number:
5500455
CAS No.:
50335-03-0 (unlabeled)
Formula:
C32H36N2O5
Molecular weight:
528,65 g/mol
This is the C13 labeled version of Chaetoglobosin A which preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton. Knudsen at al., Leukemia. 2014 Jun; 28(6):1289-98. doi: 10.1038/leu.2013.360. Epub 2013 Nov 27. Chaetoglobosin A targets filamentous actin in CLL cells and thereby induces cell-cycle arrest and inhibits membrane ruffling and cell migration. Potential mode of action/Key words: Apoptosis inducer, Targeting Tubulin
Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...
What does fermentation mean? Fermentation (from latin fermentare) is generally defined as a conversion of material under aerobic or anaerobic conditions influenced by micro-organisms. "Micro-organism" is a collective term for usually ...