Emodin

Article number:

7550736

CAS No.:

518-82-1

Formula:

C15H10O5

Synonyms:

Archin; Frangula emodin; Frangulic acid; Rheum emodin; 1,3,8-Trihydroxy 6-methyl 9,10-anthraquinone

Molecular weight:

270,24 g/mol

Emodin inhibits the proliferation of PC3 prostate cancer cells in vitro via the Notch signaling pathway. Deng G, Ju X, Meng Q, Yu ZJ, Ma LB. Mol Med Rep. 2015 Jun 12. doi: 10.3892/mmr.2015.3923. [Epub ahead of print] *** Emodin ameliorates hepatic steatosis through endoplasmic reticulum stress-sterol regulatory element binding protein 1 c pathway in liquid-fructose feeding rats. Li X, Xu Z, Wang S, Guo H, Dong S, Wang T, Zhang L, Jiang Z. Hepatol Res. 2015 May 29. doi: 10.1111/hepr.12538. [Epub ahead of print] *** Effects of emodin on the demethylation of tumor-suppressor genes in pancreatic cancer PANC-1 cells. Zhang H, Chen L, Bu HQ, Yu QJ, Jiang DD, Pan FP, Wang Y, Liu DL, Lin SZ. Oncol Rep. 2015 Jun;33(6):3015-23. doi: 10.3892/or.2015.3914. Epub 2015 Apr 17. *** Emodin regulates bone remodeling by inhibiting osteoclastogenesis and stimulating osteoblast formation. Kim JY, Cheon YH, Kwak SC, Baek JM, Yoon KH, Lee MS, Oh J. J Bone Miner Res. 2014 Jul;29(7):1541-53. doi: 10.1002/jbmr.2183. *** The anthraquinone derivative Emodin inhibits angiogenesis and metastasis through downregulating Runx2 activity in breast cancer. Ma J, Lu H, Wang S, Chen B, Liu Z, Ke X, Liu T, Fu J. Int J Oncol. 2015 Apr;46(4):1619-28. doi: 10.3892/ijo.2015.2888. Epub 2015 Feb 10. *** Emodin suppresses pulmonary metastasis of breast cancer accompanied with decreased macrophage recruitment and M2 polarization in the lungs. Jia X, Yu F, Wang J, Iwanowycz S, Saaoud F, Wang Y, Hu J, Wang Q, Fan D. Breast Cancer Res Treat. 2014 Nov;148(2):291-302. doi: 10.1007/s10549-014-3164-7. Epub 2014 Oct 14.

Plant: from rheum species like ornamental rhubarb (Rheum palmatum var. Tanguticum).

  • Has anti-cancer activity –> increasing importance for medicine
  • Effect: ankylosing spondylarthritis: it stimulates the activity of cell repair mechanisms and simultaneously of programmed cell death in the connective tissue cells (fibroblasts) that proliferate excessively in this disease
  • Inhibition of cancer cells:
    • Promyelocyte proliferation
    • Gynecological tumors
    • Oral revenge tumors
    • Liver cancer
    • Stomach cancer

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Emodin

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