Ursolic acid

Article number:


CAS No.:




Chemical description:

Ursolic acid is isolated from Arctostaphylos uva ursi. It has an antimetastatic potential, acts antiproliferative, proapoptotic and suppresses tumor invasion.


(1S,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid; (3beta)-3-Hydroxyurs-12-en-28-oic acid; Prunol; Malol; Urson; Bungeolic acid

Molecular weight:

456,70 g/mol

Ursolic acid inhibits the development of nonalcoholic fatty liver disease by attenuating endoplasmic reticulum stress. Li JS, Wang WJ, Sun Y, Zhang YH, Zheng L. Food Funct. 2015 Apr 20. [Epub ahead of print] *** Anxiolytic-like effects of ursolic acid in mice. Colla AR, Rosa JM, Cunha MP, Rodrigues AL. Eur J Pharmacol. 2015 Apr 8. pii: S0014-2999(15)00316-7. doi: 10.1016/j.ejphar.2015.03.077. [Epub ahead of print] *** Efficient delivery of ursolic acid by poly(N-vinylpyrrolidone)-block-poly (e-caprolactone) nanoparticles for inhibiting the growth of hepatocellular carcinoma in vitro and in vivo. Zhang H, Zheng D, Ding J, Xu H, Li X, Sun W.Int J Nanomedicine. 2015 Mar 11;10:1909-20. doi: 10.2147/IJN.S77125. eCollection 2015. *** Ursolic acid isolated from guava leaves inhibits inflammatory mediators and reactive oxygen species in LPS-stimulated macrophages. Kim MH, Kim JN, Han SN, Kim HK. Immunopharmacol Immunotoxicol. 2015 Mar 10:1-8. [Epub ahead of print] *** Inhibitory effects of ursolic acid on osteoclastogenesis and titanium particle-induced osteolysis are mediated primarily via suppression of NF-?B signaling. Jiang C, Xiao F, Gu X, Zhai Z, Liu X, Wang W, Tang T, Wang Y, Zhu Z, Dai K, Qin A, Wang J. Biochimie. 2015 Apr;111:107-18. doi: 10.1016/j.biochi.2015.02.002. Epub 2015 Feb 11. *** Ursolic acid and resveratrol synergize with chloroquine to reduce melanoma cell viability. Junco JJ, Mancha-Ramirez A, Malik G, Wei SJ, Kim DJ, Liang H, Slaga TJ. Melanoma Res. 2015 Apr;25(2):103-12. doi: 10.1097/CMR.0000000000000137. *** Ursolic acid inhibits the invasive phenotype of SNU-484 human gastric cancer cells. Kim ES, Moon A. Oncol Lett. 2015 Feb;9(2):897-902. Epub 2014 Nov 24.

Plant: found in apples (Malus), summer savory (Satureja hortensis), thyme (Thymus vulgaris), guava (Psidium guajava), basil (genus) (Ocimum), catnip (Nepeta cataria), lesser burnet (Prunella vulgaris), holly (Ilex), and roses (Rosaceae)

  • Action as cyclooxygenase inhibitors and their cytotoxicity, and thus their possible targeted use as anti-inflammatory and anticancer agents
  • Ursolic acid causes reduced muscle atrophy (muscle wasting)
  • In addition, a reduction of glucose, cholesterol and triglyceride levels in the blood could be measured in the experimental animals

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Ursolic acid


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