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Apigenin 4'-methyl ether; Buddleoflavonol; 5,7-Dihydroxy 4'-methoxyflavone; Linarigenin; 4'-Methoxyapigenin
Acacetin, a flavonoid, is known to exert several biological activities, like anti-peroxidative, anti-inflammatory and anti-proliferative. Latest research is also concentrating on antiarthritic effects and its use in pain management. [References: Acacetin inhibits expression of matrix metalloproteinases via a MAPK-dependent mechanism in fibroblast-like synoviocytes. Chen WP, Yang ZG, Hu PF, Bao JP, Wu LD. J Cell Mol Med. 2015 Apr 9. doi: 10.1111/jcmm.12564. [Epub ahead of print] *** Antipyretic and antinociceptive potential of extract/fractions of Potentilla evestita and its isolated compound, acacetin. Rauf A, Khan R, Khan H, Ullah B, Pervez S. BMC Complement Altern Med. 2014 Nov 18;14:448. doi: 10.1186/1472-6882-14-448. *** Protective mechanisms of acacetin against D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure in mice. Cho HI, Park JH, Choi HS, Kwak JH, Lee DU, Lee SK, Lee SM. J Nat Prod. 2014 Nov 26;77(11):2497-503. doi: 10.1021/np500537x. Epub 2014 Nov 10. *** Acacetin blocks kv1.3 channels and inhibits human T cell activation. Zhao N, Dong Q, Fu XX, Du LL, Cheng X, Du YM, Liao YH. Cell Physiol Biochem. 2014;34(4):1359-72. doi: 10.1159/000366343. Epub 2014 Oct 2. *** Acacetin (5,7-dihydroxy-4'-methoxyflavone) exhibits in vitro and in vivo anticancer activity through the suppression of NF-kB/Akt signaling in prostate cancer cells. Kim HR, Park CG, Jung JY. Int J Mol Med. 2014 Feb;33(2):317-24. doi: 10.3892/ijmm.2013.1571. Epub 2013 Nov 27.]
Plant: Verbena (Verbenae herba)
Used in pain treatment
- Anti-peroxidative, anti-inflammatory and anti-proliferative.
We open up new dimensions with phytochemicals Secondary phytochemicals are not essential for plants, but still perform important functions. These substances serve as protection against herbivores or pathogens, but also ...
With more than 1200 substances (reference substances) Cfm Oskar Tropitzsch GmbH offers a broad range of herbal reference standards for the natural products chemistry. The portfolio consists substances from all ...