Acacetin

Acacetin, a flavonoid, is known to exert several biological activities, like anti-peroxidative, anti-inflammatory and anti-proliferative. Latest research is also concentrating on antiarthritic effects and its use in pain management. [References: Acacetin inhibits expression of matrix metalloproteinases via a MAPK-dependent mechanism in fibroblast-like synoviocytes. Chen WP, Yang ZG, Hu PF, Bao JP, Wu LD. J Cell Mol Med. 2015 Apr 9. doi: 10.1111/jcmm.12564. [Epub ahead of print] *** Antipyretic and antinociceptive potential of extract/fractions of Potentilla evestita and its isolated compound, acacetin. Rauf A, Khan R, Khan H, Ullah B, Pervez S. BMC Complement Altern Med. 2014 Nov 18;14:448. doi: 10.1186/1472-6882-14-448. *** Protective mechanisms of acacetin against D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure in mice. Cho HI, Park JH, Choi HS, Kwak JH, Lee DU, Lee SK, Lee SM. J Nat Prod. 2014 Nov 26;77(11):2497-503. doi: 10.1021/np500537x. Epub 2014 Nov 10. *** Acacetin blocks kv1.3 channels and inhibits human T cell activation. Zhao N, Dong Q, Fu XX, Du LL, Cheng X, Du YM, Liao YH. Cell Physiol Biochem. 2014;34(4):1359-72. doi: 10.1159/000366343. Epub 2014 Oct 2. *** Acacetin (5,7-dihydroxy-4'-methoxyflavone) exhibits in vitro and in vivo anticancer activity through the suppression of NF-kB/Akt signaling in prostate cancer cells. Kim HR, Park CG, Jung JY. Int J Mol Med. 2014 Feb;33(2):317-24. doi: 10.3892/ijmm.2013.1571. Epub 2013 Nov 27.]