Actein

Article number:

7500382

CAS No.:

18642-44-9

Formula:

C37H56O11

Synonyms:

beta-D-Xylopyranoside; (3beta,12beta)-12-(acetyloxy)-16,23:23,26:24,25-triepoxy-26-hydroxy-9,19-cycloanostan-3-yl; Shengmating

Molecular weight:

676,85 g/mol

Actein isolated from black cohosh promotes the function of osteoblastic MC3T3-E1 cells. Lee YS, Choi EM. J Med Food. 2014 Apr;17(4):414-23. doi: 10.1089/jmf.2013.2841. Epub 2014 Feb 19. *** Actein induces calcium release in human breast cancer cells. Einbond LS, Mighty J, Redenti S, Wu HA. Fitoterapia. 2013 Dec;91:28-38. doi: 10.1016/j.fitote.2013.07.025. Epub 2013 Aug 9. *** Actein activates stress- and statin-associated responses and is bioavailable in Sprague-Dawley rats. Einbond LS, Soffritti M, Esposti DD, Park T, Cruz E, Su T, Wu HA, Wang X, Zhang YJ, Ham J, Goldberg IJ, Kronenberg F, Vladimirova A. Fundam Clin Pharmacol. 2009 Jun;23(3):311-21. doi: 10.1111/j.1472-8206.2009.00673.x. *** Actein inhibits the Na+-K+-ATPase and enhances the growth inhibitory effect of digitoxin on human breast cancer cells. Einbond LS, Shimizu M, Ma H, Wu HA, Goldsberry S, Sicular S, Panjikaran M, Genovese G, Cruz E. Biochem Biophys Res Commun. 2008 Oct 31;375(4):608-13. doi: 10.1016/j.bbrc.2008.08.054. Epub 2008 Aug 26. *** The growth inhibitory effect of actein on human breast cancer cells is associated with activation of stress response pathways. Einbond LS, Su T, Wu HA, Friedman R, Wang X, Ramirez A, Kronenberg F, Weinstein IB. Int J Cancer. 2007 Nov 1;121(9):2073-83. *** Anti-AIDS agents. Part 57: Actein, an anti-HIV principle from the rhizome of Cimicifuga racemosa (black cohosh), and the anti-HIV activity of related saponins. Sakurai N, Wu JH, Sashida Y, Mimaki Y, Nikaido T, Koike K, Itokawa H, Lee KH. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1329-32.

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Actein

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