Aeroplysinin 1

The sponge Aplysina aerophoba Schmidt belogns to the family Aplysinidae, which may be found in tropical and subtroical parts. Aeroplysinin-1, a brominated antibiotic, has a wide spectrum of anti-tumoral action and behaves as a potent anti-angiogenic compound for bovine aortic endothelia. It seems to have cytotoxic activites against HeLa tumor cells. An experimental approach confirmed effects on MCP-1 and TSP-1. Aeroplysinin reduced the viability of AML cells in a dose depentent manner with IC50 of 10-20 µm. It inhibits angiogenesis in vivo. It causes cell death of BAE cells, HCT116 and HT1080 tumor cells as well as HeLaS3 cells. Besides this it shows antileukemic activity in vivo. Aeroplysinin-1 inhibits the HIV-1 replication in a dose-dependent manner. Aeroplysinin 1, a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC50=14.6 µM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces Apoptosis in endothelial cells. Potential mode of action/Key words: Anti-angionetic, Cytotoxic, Antibiotic, Apoptosis inducer