Aloe emodin

Article number:

7550664

CAS No.:

481-72-1

Formula:

C15H10O5

Chemical description:

Synonyms:

1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione; 1,8-Dihydroxy 3-hydroxymethylanthraquinone; 3-Hydroxymethylchrysazine; Rhabarberone

Molecular weight:

270,24 g/mol

Aloe-emodin exerts a potent anticancer and immunomodulatory activity on BRAF-mutated human melanoma cells. Tabolacci C, Cordella M, Turcano L, Rossi S, Lentini A, Mariotti S, Nisini R, Sette G, Eramo A, Piredda L, De Maria R, Facchiano F, Beninati S. Eur J Pharmacol. 2015 Jun 3;762:283-292. doi: 10.1016/j.ejphar.2015.05.057. [Epub ahead of print] *** Effects of Aloe-emodin and Emodin on Proliferation of the MKN45 Human Gastric Cancer Cell Line. Chihara T, Shimpo K, Beppu H, Yamamoto N, Kaneko T, Wakamatsu K, Sonoda S. Asian Pac J Cancer Prev. 2015;16(9):3887-91. *** Modification of emodin and aloe-emodin by glycosylation in engineered Escherihia coli. Ghimire GP, Koirala N, Pandey RP, Jung HJ, Sohng JK. World J Microbiol Biotechnol. 2015 Apr;31(4):611-9. doi: 10.1007/s11274-015-1815-4. Epub 2015 Feb 7. *** Synthesis and antitumor activity of natural compound aloe emodin derivatives. Thimmegowda NR, Park C, Shwetha B, Sakchaisri K, Liu K, Hwang J, Lee S, Jeong SJ, Soung NK, Jang JH, Ryoo IJ, Ahn JS, Erikson RL, Kim BY. Chem Biol Drug Des. 2015 May;85(5):638-44. doi: 10.1111/cbdd.12448. Epub 2014 Nov 5.

Plant: Aloe (Aloe vera).

  • Is an anthraquinone and a variety of emodin contained in aloe latex, an exudate from the aloe plant
  • It has a strong stimulant and laxative effect
  • Aloe emodin is not carcinogenic when applied to the skin, although it may increase the carcinogenicity of a certain type of radiation
  • Topical application of aloin-emodin increase the sensitivity of the skin to UV light
  • Aloe-emodin is found in the gel, juice, or leaves of aloe vera, Socotrine aloe, Barbados aloe, and Zanzibar aloe, the bark of Frangula and Cascara sagrada, the leaves of Senna

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Aloe emodin

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