O HO O HO HO OH H

Alterperylenol

Article number:

5501158

CAS No.:

88899-62-1

Formula:

C20H14O6

Chemical description:

(1S,12aR,12bS)-1,4,9,12a-tetrahydroxy-2,12b-dihydro-1H-perylene-3,10-dione

Synonyms:

Alteichin

Molecular weight:

350,32 g/mol

Alterperylenol is an orange-red antifungal pigment from the plant pathogen Alternaria sp.. The fungal metabolite has an inhibitory effect on telomerase activity with an IC50 of 30 μM in the TRAP assay, making it an interesting object of research in the development of new anticancer drugs. In cancer cells, the enzyme telomerase prevents the continuous shortening of chromosome ends and is thus crucial for the infinite ability of degenerated cells to divide. Inhibition of telomerase results in premature cell death and could therefore represent a starting point for the treatment of tumor diseases.

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Alterperylenol

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