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Article number:
5600136
CAS No.:
38966-21-1
Formula:
C20H34O4
Chemical description:
(1S,2S,5R,6R,7R,10S,12R,13R)-6,13-bis(hydroxymethyl)-2,6-dimethyltetracyclo[10.3.1.01,10.02,7]hexadecane-5,13-diol
Synonyms:
(+)-Aphidicolin
Molecular weight:
338,49 g/mol
Aphidicolin is a tetracyclic diterpene antibiotic with antiviral, antineoplastic and antimitotic properties. It is a reversible inhibitor of eukaryotic nuclear DNA replication and blocks the cell cycle at early S phase. Furthermore it is known as a specific inhibitor of DNA polymerase A,D in eukaryotic cells and in some viruses. Aphidicolin belongs to the group of mycotoxins. Origin: Nigrospora oryzae. Potential mode of action/Key words: Targeting DNA, DNA Polymerase A, D inhibitor, Antibitoic, Induces Apoptosis
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