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Apoptolidin
Article number:
5500641
CAS No.:
194874-06-1
Formula:
C58H96O21
Chemical description:
(3E,5E,7E,9R,10R,11E,13E,17S,18S,20S)-20-[(R)-[(2R,3R,4S,5R,6R)-2,4-dihydroxy-6-[(2R)-2-[(2R,4S,5S,6S)-4-hydroxy-5-[(2S,4R,5R,6R)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4,6-dimethyloxan-2-yl]oxy-3-methoxypropyl]-3,5-dimethyloxan-2-yl]-hydroxymethy
Molecular weight:
1129,37 g/mol
Apoptolidin is a F0F1-ATPase inhibitor. Apotptolidin was originally isolated from Nocardiopsis sp. Antibiotic. It is an highly selective and potent apoptosis inducer in several cancer cell lines. Apoptosis in E1A-transformed cells: IC50 = 11 ng/ml; F0F1-ATPase: IC50 = 700 nM (yeast). Potential mode of action/Key words: F0F1-ATPase, Antibiotic, Apoptosis inducer
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