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Arteannuin; Winghaosu; Huanghuahaosu; Qinghaosu; Qing Hau Sau; Qing Hau Su; Qinghosu
Science 228:1049 (1985); Drugs 52:818 (1996); Trends Pharmacol Sci 20:199 (1999)
- Is a secondary plant compound, chemically a sesquiterpene.
- It is used worldwide to treat infections with multidrug-resistant strains of Plasmodium falciparum, the causative agent of malaria tropica
- The annual mugwort, from which artemisinin is extracted, is grown in China, Vietnam and East African countries . Up to two tons of leaf material can be harvested from a cultivated area of one hectare, providing two to three kilograms of the extract.
Mode of action:
- Artemisinin has a peroxide structure.
- At high concentrations of iron ions, this peroxide becomes unstable and decomposes into free radicals.
Chinese scientist Tu Youyou isolated artemisinin in the early 1970s and demonstrated its efficacy against malaria in the following decades.
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