Auristatin E

Article number:

5600006

CAS No.:

160800-57-7

Formula:

C40H69N5O7

Chemical description:

(2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-N-[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamide

Molecular weight:

732,01 g/mol

Auristatin E is a synthetic analog of Dolastatin 10. Auristatin E is a highly potent antimitotic agent.Auristatin E inhibits tubulin polymerization(1). Auristatin E-antibody cunjugates have proven to be successful anticancer agents.(2) 1. GR Pettit et al. Anticancer Drug Des. 1995 10:529. 2. SO Doronina et al. Nature Biotechnol. 2003 21:778. Auristatin E is a Tubulin inhibitor. Potential mode of action/Key words: Targeting Tubulin, Antimitotic, Anticancer, Cytotoxic

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Auristatin E

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Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...

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