Axitinib, free base

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Molecular weight:

386,47 g/mol

Axitinib is an potent and selective inhibitor of i.e. VEGFR-1, VEGFR-2 and VEGFR-3. (VEGFR=Vascular Endothelial Growth Factor Receptors). Axitinib seems to inhibit growth of breast tumors in vovo at doses of about up to 100 mg/kg. Axitinib disruptes tumor microvasulatures as measured by MRI. Axitinib is the API in the drug sold under the trade name Inlyta(R).

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Axitinib, free base

Protein Kinase Inhibitors

Protein kinases are enzymes that transfer phosphate groups from high-energy donors (typically nucleoside triphosphates) to surface exposed Serine, Threonine or Tyrosine side chains of other proteins and thus alter their ...

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