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Axitinib, free base
Axitinib is an potent and selective inhibitor of i.e. VEGFR-1, VEGFR-2 and VEGFR-3. (VEGFR=Vascular Endothelial Growth Factor Receptors). Axitinib seems to inhibit growth of breast tumors in vovo at doses of about up to 100 mg/kg. Axitinib disruptes tumor microvasulatures as measured by MRI. Axitinib is the API in the drug sold under the trade name Inlyta(R).
Protein Kinase Inhibitors
Protein kinases are enzymes that transfer phosphate groups from high-energy donors (typically nucleoside triphosphates) to surface exposed Serine, Threonine or Tyrosine side chains of other proteins and thus alter their ...