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Baclofen is a GABA derivative that acts as an agonist at GABA-B receptors; it is commonly used in animal models to examine the effects of GABAergic neurotransmission in a variety of fields, including substance dependence, spasticity, pain, and feeding behavior. Baclofen exhibits analgesic, antinociceptive, and antiepileptic/anticonvulsant activities. Baclofen is used clinically to promote abstinence in alcohol dependent subjects, potentially mediating alcohol craving during withdrawal. This compound is also delivered intrathecally to treat spasticity and dystonia.
Generally an excipient is a pharmacologically inactive substance used as a carrier for the active ingredient (API) of a medication. In many cases, an "active" substance may not be easily administered and ...
Pharmaceutical raw materials are the basis for the production of drugs and can be divided into three categories: Natural products are drugs with vegetable ingredients called Phytopharmaka. These days the majority of them ...