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Article number:
7500633
CAS No.:
472-15-1
Formula:
C30H48O3
Chemical description:
Betulinic acid is isolated from Platanus acerifolia. Its pharmacological properties are anti-malarial, anti-protozoal, anti-HIV, anti-inflammatory, anthelmintic, proapoptotic.
Synonyms:
(1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid; 3ß-Hydroxy-lup-20(29)-en-28-säure, 3-beta-Hydroxy-20(29
Molecular weight:
456,70 g/mol
Betulinic acid induces a novel cell death pathway that depends on cardiolipin modification.Potze L, Di Franco S, Grandela C, Pras-Raves ML, Picavet DI, van Veen HA, van Lenthe H, Mullauer FB, van der Wel NN, Luyf A, van Kampen AH, Kemp S, Everts V, Kessler JH, Vaz FM, Medema JP.Oncogene. 2015 Apr 20. doi: 10.1038/onc.2015.102. [Epub ahead of print]***Sequential treatment with betulinic acid fo llowed by 5-fluorouracil shows synergistic cytotoxic activity in ovarian cancer cells.Wang YJ, Liu JB, Dou YC. Int J Clin Exp Pathol. 2015 Jan 1;8(1):252-9. eCollection 2015.***Betulinic acid atten uates renal oxidative stress and inflammation in experimental model of murine polymicrobial sepsis.Lingaraju MC, Pathak NN, Begum J, Balaganur V, Ramachandra HD, Bhat RA, Ram M, Singh V, Kandasamy K, Kumar D, Kumar D, Tandan SK.Eur J Pharm Sci. 2015 Apr 5;70:12-21. doi: 10.1016/j.ejps.2015.01.001. Epub 2015 Jan 10.***Characterization and in vitro studies of the anticancer effect of oxidized ca rbon nanotubes functionalized with betulinic acid.Tan JM, Karthivashan G, Arulselvan P, Fakurazi S, Hussein MZ.Drug Des Devel Ther. 2014 Nov 20;8:2333-43. doi: 10.2147/DDDT.S70650. eCollection 2014. ***Investigation of antimalarial activity, cytotoxicity and action mechanism of piperazine derivatives of betulinic acid.Silva GN, Schuck DC, Cruz LN, Moraes MS, Nakabashi M, Gosmann G, Garcia CR, G noatto SC.Trop Med Int Health. 2015 Jan;20(1):29-39. doi: 10.1111/tmi.12395. Epub 2014 Oct 13.***Bet
With more than 1200 substances (reference substances) Cfm Oskar Tropitzsch GmbH offers a broad range of herbal reference standards for the natural products chemistry. The portfolio consists substances from all ...