Article number:


CAS No.:




Chemical description:



Molecular weight:

326,30 g/mol

Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation. Jiang M, Li J, Peng Q, Liu Y, Liu W, Luo C, Peng J, Li J, Yung KK, Mo Z. J Neuroinflammation. 2014 Sep 26;11:167. doi: 10.1186/s12974-014-0167-6. *** Bilobalide attenuates hypoxia induced oxidative stress, inflammation, and mitochondrial dysfunctions in 3T3-L1 adipocytes via its antioxidant potential. Priyanka A, Nisha VM, Anusree SS, Raghu KG. Free Radic Res. 2014 Oct;48(10):1206-17. doi: 10.3109/10715762.2014.945442. *** Bilobalide induces neuronal differentiation of P19 embryonic carcinoma cells via activating Wnt/ß-catenin pathway. Liu M, Guo J, Wang J, Zhang L, Pang T, Liao H. Cell Mol Neurobiol. 2014 Aug;34(6):913-23. doi: 10.1007/s10571-014-0072-7. Epub 2014 May 18. *** Neurodegeneration after transient brain ischemia in aged mice: beneficial effects of bilobalide. Schwarzkopf TM, Koch KA, Klein J. Brain Res. 2013 Sep 5;1529:178-87. doi: 10.1016/j.brainres.2013.07.003. Epub 2013 Jul 11. *** Protective effect of bilobalide on learning and memory impairment in rats with vascular dementia. Li WZ, Wu WY, Huang H, Wu YY, Yin YY. Mol Med Rep. 2013 Sep;8(3):935-41. doi: 10.3892/mmr.2013.1573. Epub 2013 Jul 8. *** Effects of bilobalide on anxiety, spatial learning, memory and levels of hippocampal glucocorticoid receptors in male Kunming mice. Ma L, Wang S, Tai F, Yuan G, Wu R, Liu X, Wei B, Yang X. Phytomedicine. 2012 Dec 15;20(1):89-96. doi: 10.1016/j.phymed.2012.09.015. Epub 2012 Oct 17. *** Neuroprotective effects of bilobalide are accompanied by a reduction of ischemia-induced glutamate release in vivo. Lang D, Kiewert C, Mdzinarishvili A, Schwarzkopf TM, Sumbria R, Hartmann J, Klein J. Brain Res. 2011 Nov 24;1425:155-63. doi: 10.1016/j.brainres.2011.10.005. Epub 2011 Oct 6.

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