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Article number:
5501166
CAS No.:
9041-93-4
Formula:
C55H82N17O21S3*H2SO4
Synonyms:
Blenoxan, Blenoxane, Bleomycin B2, BLEOcell
Molecular weight:
1512,62 g/mol
Bleomycin is an antineoplastic antibiotic isolated from the bacterium Streptomyces verticillus which binds to DNA and inhibits DNA synthesis. Its mechanism of action causes single- and double-strand DNA breaks in tumor cells, which interrupts the cell cycle. Bleomycin is thought to achieve this by chelating metal ions, producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. Bleomycin has been used for the treatment of Hodgkin's lymphoma in combination with doxorubicin, squamous cell carcinomas, testicular cancer, as well as in animal models of pulmonary fibrosis. Bleomycin Sulfate (A mixture of bleomycin sulfate salts).
What does fermentation mean? Fermentation (from latin fermentare) is generally defined as a conversion of material under aerobic or anaerobic conditions influenced by micro-organisms. "Micro-organism" is a collective term for usually ...