O HN N HN O O NH O O N OH OH O HO OH N H 2 N HO H N H N O O OH OH NH 2 O NH 2 O H 2 N NH O HO H 2 N O N S S N N H O S + O HN N HN O O NH O O N OH OH O HO OH N H 2 N HO H N H N O O OH OH NH 2 O NH 2 O H 2 N NH O HO H 2 N O N S S N N H O S + S O O - O O -

Bleomycin sulfate

Article number:

5501166

CAS No.:

9041-93-4

Formula:

C55H82N17O21S3*H2SO4

Synonyms:

Blenoxan, Blenoxane, Bleomycin B2, BLEOcell

Molecular weight:

1512,62 g/mol

Bleomycin is an antineoplastic antibiotic isolated from the bacterium Streptomyces verticillus which binds to DNA and inhibits DNA synthesis. Its mechanism of action causes single- and double-strand DNA breaks in tumor cells, which interrupts the cell cycle. Bleomycin is thought to achieve this by chelating metal ions, producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. Bleomycin has been used for the treatment of Hodgkin's lymphoma in combination with doxorubicin, squamous cell carcinomas, testicular cancer, as well as in animal models of pulmonary fibrosis. Bleomycin Sulfate (A mixture of bleomycin sulfate salts).

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Bleomycin sulfate

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