N OH OH O O H OH O

Borrelidin

Article number:

5500643

CAS No.:

7184-60-3

Formula:

C28H43NO6

Chemical description:

2-(7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6-dien-2-yl)cyclopentane-1-carboxylic acid

Synonyms:

Treponemycin

Molecular weight:

489,60 g/mol

Borrelidin is an angiogenesis inhibitor that induces apoptosis of the capillary tube-forming cells. It also displays antimalarial activity against drug-resistant Plasmodia. Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor which is a nitrile-containing macrolide antibiotic isolated from Streptomyces rochei. Potential mode of action/Key words: Angiogenesis inhibitor, Apoptosis inducer, Antibiotic, Thr-tRNA synthetase inhibitor

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Borrelidin

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