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Bosutinib, free base
Bosutinib is an active inhibitor of Bcr-Abl in several chronic myelogenous leukemia cell lines. Bosutinib inhibits tumor cell proliferation, angiogenesis, growth factor expression in vivo. Bosutinib is a novel tyrosine kinase inhibitor.
Protein Kinase Inhibitors
Protein kinases are enzymes that transfer phosphate groups from high-energy donors (typically nucleoside triphosphates) to surface exposed Serine, Threonine or Tyrosine side chains of other proteins and thus alter their ...