Bufalin

Article number:

5600070

CAS No.:

465-21-4

Formula:

C24H34O4

Chemical description:

5-[(3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pyran-2-one

Synonyms:

Bufadienolide

Molecular weight:

386,53 g/mol

Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1. Bufalin strongly promotes SRC-3 protein degradation and blocks cancer cell growth at nanomolar concentrations. Besides this Bufalin acts as an DNA topoisomerases I and II inhibitor.

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Bufalin

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Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...

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