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Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1. Bufalin strongly promotes SRC-3 protein degradation and blocks cancer cell growth at nanomolar concentrations. Besides this Bufalin acts as an DNA topoisomerases I and II inhibitor.
Cfm Oskar Tropitzsch GmbH supplies unique molecules - in this case the cytotoxins for antibodies. These payloads are ultra-toxic drugs, i.e. cytotoxic and/or cytostatic molecules, effective at a low dosage and ...