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(2S,3R,4S,5S,6R)-2-[[(1aS,1bS,2S,5aR,6S,6aS)-6-hydroxy-1a-(hydroxymethyl)-2,5a,6,6a-tetrahydro-1bH-oxireno[5,6]cyclopenta[1,3-c]pyran-2-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol; Catalpinoside; De(p-hydroxybenzoyl)catalposide
Catalpol protects mice against renal ischemia/reperfusion injury via suppressing PI3K/Akt-eNOS signaling and inflammation. Zhu J, Chen X, Wang H, Yan Q. Int J Clin Exp Med. 2015 Feb 15;8(2):2038-44. eCollection 2015. *** Potential Neurogenesis of Human Adipose-Derived Stem Cells on Electrospun Catalpol-Loaded Composite Nanofibrous Scaffolds. Guo JH, Liu Y, Lv ZJ, Wei WJ, Guan X, Guan QL, Leng ZQ, Zhao JY, Miao H, Liu J. Ann Biomed Eng. 2015 Mar 31. [Epub ahead of print] *** Catalpol regulates cholinergic nerve system function through effect on choline acetyl-transferase not M receptor affinity. Wang JH, Xie H, Zhao TK, Kang B. Biomed Pharmacother. 2015 Feb;69:291-6. doi: 10.1016/j.biopha.2014.12.014. Epub 2014 Dec 19. *** Catalpol: a potential therapeutic for neurodegenerative diseases. Jiang B, Shen RF, Bi J, Tian XS, Hinchliffe T, Xia Y. Curr Med Chem. 2015;22(10):1278-91. *** Catalpol Inhibited the Proliferation of T24 Human Bladder Cancer Cells by Inducing Apoptosis Through the Blockade of Akt-Mediated Anti-apoptotic Signaling. Jin D, Cao M, Mu X, Yang G, Xue W, Huang Y, Chen H. Cell Biochem Biophys. 2014 Nov 12. [Epub ahead of print] *** Catalpol suppresses proliferation and facilitates apoptosis of OVCAR-3 ovarian cancer cells through upregulating microRNA-200 and downregulating MMP-2 expression. Gao N, Tian JX, Shang YH, Zhao DY, Wu T. Int J Mol Sci. 2014 Oct 24;15(11):19394-405. doi: 10.3390/ijms151119394.
Isolated from the plant Catalpa bignonioides (Bignoniaceae), native to North America and East Asia.
- Catalpol occurs predominantly as esters of various aromatic carboxylic acids
- Is the most abundant iridoid glucoside besides aucubin
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