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Chaetocin
Article number:
5500644
CAS No.:
28097-03-2
Formula:
C30H28N6O6S4
Chemical description:
14-(hydroxymethyl)-3-[14-(hydroxymethyl)-18-methyl-13,17-dioxo-15,16-dithia-10,12,18-triazapentacyclo[12.2.2.01,12.03,11.04,9]octadeca-4,6,8-trien-3-yl]-18-methyl-15,16-dithia-10,12,18-triazapentacyclo[12.2.2.01,12.03,11.04,9]octadeca-4,6,8-triene-13
Molecular weight:
696,84 g/mol
Chaetocin is an antitumor antibiotic. It is a thiodioxopiperazine natural product produced by Chaetomium species. Specific inhibitor of the lysine-specific methyltransferase SU. It displays potent antimyeloma activity in IL-6-dependent myeloma cell lines. Its antimyeloma activity appears to be due to induction of oxidative stress and consequent apoptosis. Potential mode of action/Key words: ROS generation, Apoptosis inducer, Antibiotic, Antitumoral
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