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Chaetomin; NSC289491; BRN0077366
Chetomin is a natural metabolite, which blocks the interaction of HIF1alfa and HIF2alfa with transcriptional co-activators p300 and cAMP response element binding protein, thereby attenuating hypoxia-inducible transcription. Chetomin also suppresses the proliferation of LPS-induced mouse spleen lymphocytes.
Selman Waksman defined the term antibiotic in 1942 to describe any substance produced by a microorganism that is antagonistic to the growth of other microorganisms in high dilution. While this ...