Cytotrienin A
Article number:
5500028
CAS No.:
189010-85-3
Formula:
C37H48N2O8
Chemical description:
1-[(1-cyclohexen-1-ylcarbonyl)amino]-15R,22,24-trihydroxy-5R-methoxy-14R,16Z-dimethyl-3-oxo-2-azabicyclo[18.3.1]tetracosa-1(24),6E,8E,10E,16,20,22-heptaen-13S-yl ester-cyclopropanecarboxylic acid
Molecular weight:
648,79 g/mol
Cytotrienin A is an anti-tumor agent isolated from Steptomyces species. Cyt A is an ansamycin. Cytotrienin A induces apoptosis on HL-60 cells, as well as inhibiting translation in eukaryotes by inhibiting eukaryotic elongation factor 1A (eEF1A), which can act as an oncogene.These functions lead to the potential of the microbial metabolite acting as an anticancer agent, specifically for blood cancers, as it has proved to be more effective with leukemic cell lines. Cyt A is thought to induce apoptosis by activating c-Jun N-terminal Kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and p36 myelin basic protein (MBP) kinase. Potential mode of action: Targeting RNA, Translation inhibitor, Antitumoral
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